INT262826

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.83
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1, TNF) extracellular region (Serpinf1, TNF) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
capillary 2
Serpinf1 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 97.48 Very High Very High Very High
cytokine 4 93.96 High High
Multiple sclerosis 4 91.68 High High
ischemia 6 76.48 Quite High
glial activation 2 26.04 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 99.68 Very High Very High Very High
INFLAMMATION 38 97.48 Very High Very High Very High
Diabetes Mellitus 4 94.96 High High
Neurodegenerative Disease 2 94.72 High High
Demyelinating Disease 4 91.68 High High
Diabetic Retinopathy 6 90.96 High High
Parkinson's Disease 2 90.08 High High
Alzheimer's Dementia 2 88.24 High High
Glaucoma 74 81.60 Quite High
Cv Unclassified Under Development 4 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured retinal capillary endothelial cells, PEDF significantly decreased TNF expression due to hypoxia.
PEDF Negative_regulation (decreased) of Gene_expression (expression) of TNF in capillary associated with hypoxia
1) Confidence 0.29 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.98 Pain Relevance 0.21
These findings indicate that PEDF potently and efficaciously reduces RGC loss in DBA/2J mice, reduces expression of TNF and IL-18, and downregulates GFAP.
PEDF Negative_regulation (reduces) of Gene_expression (expression) of TNF
2) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.85 Pain Relevance 0.08

General Comments

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