INT26289

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Context Info
Confidence 0.11
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map3k12) plasma membrane (Map3k12) cytoplasm (Map3k12)
Anatomy Link Frequency
dentate gyrus 1
tail 1
Map3k12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
tail-flick 14 98.96 Very High Very High Very High
Analgesic 21 98.08 Very High Very High Very High
Antinociceptive 17 96.08 Very High Very High Very High
antinociception 7 75.68 Quite High
Opioid 30 50.00 Quite Low
Morphine 9 31.60 Quite Low
intrathecal 4 30.40 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Burns 1 14.60 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Constipation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this experiment, increasing doses of PK20 (0.5-0.005 nmol/rat) were administered and its analgesic effect was evaluated within a period of 2 hours by means of the tail-flick test.
Positive_regulation (increasing) of PK20 in tail associated with analgesic and tail-flick
1) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017538 Disease Relevance 0 Pain Relevance 0.62
Urethane-anesthetized rats with perforant pathway stimulating electrodes and recording electrodes placed in the hippocampal dentate gyrus were exposed to increasing doses of either the benzodiazepine agonist diazepam or an antagonist (PK-11195, CGS-8216, and RO15-1788).
Positive_regulation (increasing) of PK-11195 in dentate gyrus associated with antagonist and agonist
2) Confidence 0.07 Published 1989 Journal Exp. Neurol. Section Abstract Doc Link 2553469 Disease Relevance 0 Pain Relevance 0.17

General Comments

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