INT2629

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Context Info
Confidence 0.72
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 15.12
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
blood 3
inferior 2
central nervous system 1
testis 1
blood vessel 1
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 25 99.52 Very High Very High Very High
opiate 8 98.96 Very High Very High Very High
antagonist 87 98.68 Very High Very High Very High
narcan 13 97.92 Very High Very High Very High
Pain 4 93.88 High High
Dismenorea 2 93.36 High High
beta blocker 33 90.52 High High
headache 34 80.88 Quite High
Opioid 4 80.20 Quite High
Calcium channel 43 79.12 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 119 99.90 Very High Very High Very High
Emergencies 47 99.72 Very High Very High Very High
Hypertension 768 99.52 Very High Very High Very High
Stress 72 99.16 Very High Very High Very High
Hypoxia 128 99.00 Very High Very High Very High
Fatigue 10 98.72 Very High Very High Very High
Hypertrophy 15 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 24 98.04 Very High Very High Very High
Fibrocystic Breast Disease 1 97.32 Very High Very High Very High
Diabetes Mellitus 182 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of their ability to suppress sex hormone secretion and the supposed role of these hormones in the physiopathology of fibrocystic mastopathy, GNRHAs have been proposed for the management of severe breast pain and nodularity.
Localization (secretion) of sex hormone associated with pain and fibrocystic breast disease
1) Confidence 0.72 Published 1994 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 8005138 Disease Relevance 0.70 Pain Relevance 0.17
The unaltered intratesticular T production contrasted with significantly lowered serum T concentration may reflect a reduction in sex hormone binding globulin (SHBG) essential for T transportation in blood [46].
Localization (globulin) of sex hormone in blood
2) Confidence 0.67 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.60 Pain Relevance 0
In addition, it is suggested that the inherent arteriosclerotic inelasticity of vessels in SHR also prolongs the decrease in SBP, even after relief from hypoxic stress, because arteriosclerosis has been shown to bring about weakening of sympathetically mediated vasoconstriction (Boddaert et al., 2004).
Localization (decrease) of SBP in vessels associated with stress, hypoxia and increased venous pressure under development
3) Confidence 0.49 Published 2008 Journal Autonomic Neuroscience Section Body Doc Link PMC2941824 Disease Relevance 1.09 Pain Relevance 0.14
Power spectral analysis of HR and SBP variability by wavelet method
Localization (variability) of SBP associated with heart rate under development
4) Confidence 0.49 Published 2008 Journal Autonomic Neuroscience Section Body Doc Link PMC2941824 Disease Relevance 0.78 Pain Relevance 0
These effects may depend on both estrogenic and androgenic actions exerted at the genital level and in the central nervous system, and on a reduction of sex-hormone-binding globulin and an increase of free testosterone, without affecting ?
Localization (increase) of sex-hormone-binding globulin in central nervous system associated with central nervous system
5) Confidence 0.48 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2671819 Disease Relevance 0.87 Pain Relevance 0.26
MAIN RESULTS: Logistic correlation coefficient values for SBP and DBP decreases were larger than the cubic correlation coefficient values (0.990 [Z transformation: 2.64 +/- 0.32] vs 0.981 [Z: 2.32 +/- 0.37] and 0.977 [Z: 2.22 +/- 0.33] vs 0.967 [Z: 2.05 +/- 0.34], respectively; P < 0.05).
Localization (decreases) of SBP
6) Confidence 0.46 Published 2007 Journal J Clin Anesth Section Body Doc Link 18063203 Disease Relevance 0 Pain Relevance 0
In subgroup analyses of younger patients (men aged 70 years or younger and women aged 75 years or younger), we found similar point estimates for initiation and intensification of lipid-lowering therapy, but age and SBP were not statistically significant determinants anymore.
Localization (age) of SBP
7) Confidence 0.36 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC2034374 Disease Relevance 1.42 Pain Relevance 0.05
Approximately 90% of patients reached their SBP target within 30 minutes (the primary efficacy end point), which persisted for a minimum of 18 hours.
Localization (target) of SBP
8) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922306 Disease Relevance 0.28 Pain Relevance 0
As expected, in all exercise protocols and in both groups, SBP and DBP increased significantly during the exercise sets and decreased during the rest periods.
Localization (decreased) of SBP
9) Confidence 0.26 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845767 Disease Relevance 0.24 Pain Relevance 0
Nevertheless, the elevation of SBP increases the sheer stress and fatigue on arterial walls, accelerating arterial damage, exacerbating the arterial changes and atherosclerosis, creating a vicious cycle of plaque formation and rupture, further blood vessel damage, and loss of arterial distensibility.
Localization (elevation) of SBP in blood vessel associated with stress, rupture, atherosclerosis and fatigue
10) Confidence 0.20 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.21 Pain Relevance 0
The release of [3H]5-HT and its binding protein, SBP, from the guinea pig enteric nervous system was analyzed.
Spec (analyzed) Localization (release) of SBP in enteric nervous system
11) Confidence 0.15 Published 1979 Journal Brain Res. Section Abstract Doc Link 487123 Disease Relevance 0 Pain Relevance 0.18
Different primary end points were defined in these studies: the reduction in DBP, either from baseline (Karlberg et al 1999; Lacourciére et al 2001; McGill and Reilly 2001b; Lacourciére and Martin 2002; Freytag et al 2002) or to values inferior to 90 mmHg (Neutel et al 2002; Freytag et al 2002); changes in ambulatory DBP and SBP (Lacourciére et al 2003); and decreases in supine SBP (Karlberg et al 1999; Freytag et al 2001).
Localization (decreases) of SBP in inferior
12) Confidence 0.15 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0
Different primary end points were defined in these studies: the reduction in DBP, either from baseline (Karlberg et al 1999; Lacourciére et al 2001; McGill and Reilly 2001b; Lacourciére and Martin 2002; Freytag et al 2002) or to values inferior to 90 mmHg (Neutel et al 2002; Freytag et al 2002); changes in ambulatory DBP and SBP (Lacourciére et al 2003); and decreases in supine SBP (Karlberg et al 1999; Freytag et al 2001).
Localization (decreases) of SBP in inferior
13) Confidence 0.15 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0
A marked increase in SBP (but not LDH) release was provoked by electrical field stimulation at 10 Hz, and this increased release (but not the spontaneous release) was Ca2+-dependent.
Localization (release) of SBP
14) Confidence 0.13 Published 1979 Journal Brain Res. Section Abstract Doc Link 487123 Disease Relevance 0.09 Pain Relevance 0.19
In this study the key factor to predict normalization of both SBP and DBP was the severity of hypertension.
Localization (normalization) of SBP associated with hypertension
15) Confidence 0.12 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993978 Disease Relevance 1.33 Pain Relevance 0.06
It is concluded that SBP and 5-HT are probably stored together, at least in part in vesicles, and that both can be released by exocytosis from depolarized axon terminals.
Localization (released) of SBP in vesicles
16) Confidence 0.12 Published 1979 Journal Brain Res. Section Abstract Doc Link 487123 Disease Relevance 0.08 Pain Relevance 0.17
Variation of SBP and DBP were similar for men and women.
Localization (Variation) of SBP
17) Confidence 0.11 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993978 Disease Relevance 0.84 Pain Relevance 0.06
The target of SBP <140 mmHg and DBP <90 mmHg was achieved at week 4 by 1267 patients (42.9%) and at week 8 by 1865 patients (65.5%) (Figure 1).
Localization (target) of SBP
18) Confidence 0.11 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993978 Disease Relevance 0.40 Pain Relevance 0.05
The results of these studies suggest that intratesticular opiates exert a suppressive effect on Sertoli cell growth and rABP secretion.
Localization (secretion) of rABP in Sertoli cell associated with opiate
19) Confidence 0.09 Published 1986 Journal Endocrinology Section Abstract Doc Link 3698906 Disease Relevance 0.37 Pain Relevance 0.48
Both DBP and SBP were measured at weeks 4, 8, and 12 of each study.
Localization (measured) of SBP
20) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663442 Disease Relevance 0.17 Pain Relevance 0

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