INT262908

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.00
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
plasma 2
blood 2
astrocytes 1
central nervous system 1
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 67 100.00 Very High Very High Very High
Central nervous system 1 100.00 Very High Very High Very High
antagonist 1 98.08 Very High Very High Very High
agonist 1 96.64 Very High Very High Very High
Inflammation 38 94.08 High High
metalloproteinase 1 94.00 High High
Serotonin 1 92.84 High High
Neurotransmitter 2 82.44 Quite High
antidepressant 1 75.24 Quite High
Inflammatory response 8 72.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 100.00 Very High Very High Very High
Depression 48 99.84 Very High Very High Very High
Injury 6 96.20 Very High Very High Very High
Recurrence 21 95.92 Very High Very High Very High
INFLAMMATION 48 94.08 High High
Birth Weight 23 93.64 High High
Stress 20 84.20 Quite High
Death 9 83.28 Quite High
Leishmaniasis 33 73.80 Quite High
Infection 48 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, astrocytes which release IL-10 in the central nervous system and are especially sensitive to the apoptotic effects of quinolinic acid, have been observed to be reduced in MDD [16,17].
Negative_regulation (reduced) of in astrocytes Localization (release) of IL-10 in central nervous system associated with depression, central nervous system and apoptosis
1) Confidence 0.43 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 1.43 Pain Relevance 0.62
This is in line with data showing inhibition of intervillous blood mononuclear cells (IVBMCs) charged in HZ and in particular suppression of PGE2, TNF, and IL-10 secretion [33,34].
Negative_regulation (suppression) of Localization (secretion) of IL-10 in blood
2) Confidence 0.37 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 0.67 Pain Relevance 0.08
Insignificant decrease of plasma IL-12 and IL-10, negligible increase of Th1-cytokines, and persistence of IL-10, despite decrease in TGF-?
Negative_regulation (decrease) of Localization (decrease) of IL-10 in plasma associated with cytokine
3) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.61 Pain Relevance 0.16
Our data further demonstrated that exposure of cells to ultrafine particles resulted in diminished IL-10 and VEGF release.
Negative_regulation (diminished) of Localization (release) of IL-10
4) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.56 Pain Relevance 0.29
As with diesel exhaust particle exposure, we believe that the production of ROS by the ultrafine particle systems is responsible for this decrease in IL-10 and VEGF secretion, but further investigation, is required to determine and clarify this mechanism.
Negative_regulation (decrease) of Localization (secretion) of IL-10
5) Confidence 0.10 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.72 Pain Relevance 0.35

General Comments

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