INT262928

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.11
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENPP2) extracellular region (ENPP2) plasma membrane (ENPP2)
transcription factor binding (ENPP2)
Anatomy Link Frequency
facets 2
ENPP2 (Homo sapiens)
ENPP2 - H226Q (2) ENPP2 - H434Q (1)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 63.20 Quite High
Multiple sclerosis 6 58.72 Quite High
Neuropathic pain 6 56.72 Quite High
adenocard 12 45.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer 24 99.28 Very High Very High Very High
Metastasis 6 97.08 Very High Very High Very High
Obesity 6 65.68 Quite High
Rheumatoid Arthritis 6 63.20 Quite High
Alzheimer's Dementia 6 61.12 Quite High
Demyelinating Disease 6 58.72 Quite High
Neuropathic Pain 6 56.72 Quite High
Skin Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autotaxin (ATX, NPP2), a secreted enzyme originally purified as a tumor cell motility-stimulating factor [1], enhances the tumorigenic and metastatic potential of transformed cells [2], and stimulates angiogenic activity in Matrigel™ plug assays [3], thereby affecting several facets of oncogenic progression.
Localization (secreted) of NPP2 in facets associated with cancer
1) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0.46 Pain Relevance 0.12
Autotaxin (ATX, NPP2), a secreted enzyme originally purified as a tumor cell motility-stimulating factor [1], enhances the tumorigenic and metastatic potential of transformed cells [2], and stimulates angiogenic activity in Matrigel™ plug assays [3], thereby affecting several facets of oncogenic progression.
Localization (secreted) of Autotaxin in facets associated with cancer
2) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0.46 Pain Relevance 0.12
The secreted enzyme autotaxin (ATX) stimulates tumor cell migration, tumorigenesis, angiogenesis, and metastasis.
Localization (secreted) of enzyme autotaxin associated with cancer and metastasis
3) Confidence 0.58 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2649126 Disease Relevance 0.20 Pain Relevance 0
To better understand the altered hydrolytic efficiency and substrate selectivity of H226Q-ATX and H434Q-ATX, we determined the effects of substrate concentrations on the reaction rates and calculated the kinetic parameters Km and Vmax for each substrate.
Localization (selectivity) of H226Q-ATX (H226Q)
4) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
To better understand the altered hydrolytic efficiency and substrate selectivity of H226Q-ATX and H434Q-ATX, we determined the effects of substrate concentrations on the reaction rates and calculated the kinetic parameters Km and Vmax for each substrate.
Localization (selectivity) of H434Q-ATX (H434Q)
5) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
When H226Q-ATX is compared to WT-ATX, Vmax is lower for all substrates tested, but these changes are disproportionately large for FS-3 and pNpTMP compared to LPC (18:1).
Localization (compared) of H226Q-ATX (H226Q)
6) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0

General Comments

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