INT262954

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAX6) nucleolus (PAX6) nucleus (PAX6)
DNA binding (PAX6) transcription factor binding (PAX6) cytoplasm (PAX6)
PAX6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 5 66.64 Quite High
imagery 17 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 29 99.98 Very High Very High Very High
Cancer 120 99.72 Very High Very High Very High
Aniridia 63 81.96 Quite High
Subependymal Glioma 62 80.20 Quite High
Disease 2 79.36 Quite High
Intellectual Impairment 6 73.64 Quite High
Brain Tumor 8 71.24 Quite High
Nervous System Malformation 2 67.12 Quite High
Glioma 16 52.24 Quite High
Inborn Genetic Diseases 8 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These regions may be frequently methylated in tumors, which could affect the transcription of PAX6 and tumorigenesis, though we did not address this issue in the present study because we do not have neighboring normal tissue, making the comparison of DNA methylation status between tumor and normal tissues impossible.
Regulation (affect) of Transcription (transcription) of PAX6 associated with cancer
1) Confidence 0.62 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 1.19 Pain Relevance 0
Therefore, if the two different deletions were located on the same chromosome, we could not amplify any portions of PAX6 transcript from the tumor tissue including the region that corresponds to the 3?
Neg (not) Regulation (portions) of Transcription (transcript) of PAX6 associated with cancer
2) Confidence 0.45 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 0.60 Pain Relevance 0
It could allow us to detect possible alternative splicing abnormalities affecting the length and the sequence of the PAX6 transcripts.
Spec (possible) Regulation (affecting) of Transcription (sequence) of PAX6 associated with congenital anomalies
3) Confidence 0.27 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2649307 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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