INT262964

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAX6) nucleolus (PAX6) nucleus (PAX6)
DNA binding (PAX6) transcription factor binding (PAX6) cytoplasm (PAX6)
Anatomy Link Frequency
retina 2
PAX6 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 9 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 76.92 Quite High
Aniridia 35 68.80 Quite High
Syndrome 5 65.32 Quite High
Ocular Toxicity (including Many Sub-types) 3 60.12 Quite High
Cataract 16 58.64 Quite High
Eye Malformation 3 57.88 Quite High
Congenital Anomalies 21 50.44 Quite High
Nystagmus 10 5.00 Very Low Very Low Very Low
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Cerebellar Diseases 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This insertion abolishes Pax6 DNA-binding properties [3] and seems to induce, when the Pax6(+5a) isoform is overexpressed, a developmental cascade modifying the neuronal architecture of the retina [4].
Negative_regulation (abolishes) of Pax6 Binding (binding) of in retina
1) Confidence 0.43 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2649307 Disease Relevance 0.44 Pain Relevance 0

General Comments

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