INT262994

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.02
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1)
extracellular region (CRP) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plaque 2
CRP (Homo sapiens)
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 63.24 Quite High
Angina 10 32.92 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 36 100.00 Very High Very High Very High
Diabetes Mellitus 22 100.00 Very High Very High Very High
Obesity 20 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 12 100.00 Very High Very High Very High
Hypertension 8 100.00 Very High Very High Very High
Nicotine Addiction 8 100.00 Very High Very High Very High
Heart Rate Under Development 22 99.32 Very High Very High Very High
Atherosclerosis 34 99.18 Very High Very High Very High
Atherosclerotic Plaque 32 96.96 Very High Very High Very High
Calcification 6 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume, adiponectin levels were predictive of coronary atherosclerotic plaque burden, i.e. an increase in adiponectin levels by 27.8 µg/ml is associated with the reduction of one atherosclerotic plaque (estimate: ?
hsCRP Binding (history) of HDL in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerotic plaque, obesity, hypertension and disorder of lipid metabolism
1) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.62 Pain Relevance 0
Our data support the concept that adiponectin is an important marker in the pathogenesis of atherosclerosis since adiponectin remains significantly associated with plaque morphology in a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume.
hsCRP Binding (associated) of HDL in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerosis, hypertension, obesity and disorder of lipid metabolism
2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.40 Pain Relevance 0.03

General Comments

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