INT262999

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 9.52
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
liver 2
plaque 2
adipose tissue 2
upper 2
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 88.20 High High
Angina 18 75.92 Quite High
ischemia 2 42.52 Quite Low
headache 1 32.44 Quite Low
Inflammation 7 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 173 100.00 Very High Very High Very High
Heart Rate Under Development 85 99.82 Very High Very High Very High
Atherosclerotic Plaque 48 99.48 Very High Very High Very High
Cancer 19 99.08 Very High Very High Very High
Disorder Of Lipid Metabolism 45 98.94 Very High Very High Very High
Coronary Artery Disease 59 98.70 Very High Very High Very High
Diabetes Mellitus 45 98.68 Very High Very High Very High
Nicotine Addiction 14 98.24 Very High Very High Very High
Insulin Resistance 39 98.04 Very High Very High Very High
Stomach Cancer 2 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of adiponectin are markedly decreased in patients with visceral obesity and states of insulin resistance such as non-alcoholic fatty liver disease and type 2 diabetes [7], [8].
Negative_regulation (decreased) of Gene_expression (levels) of adiponectin in liver associated with diabetes mellitus, obesity, disease, alcoholic fatty liver and insulin resistance
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 2.15 Pain Relevance 0.12
However, comparing adiponectin concentrations in serum aliquots stored for 21 and 33 months at ?
Negative_regulation (comparing) of Gene_expression (concentrations) of adiponectin
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.55 Pain Relevance 0
In a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume, adiponectin levels were predictive of coronary atherosclerotic plaque burden, i.e. an increase in adiponectin levels by 27.8 µg/ml is associated with the reduction of one atherosclerotic plaque (estimate: ?
Negative_regulation (predictive) of Gene_expression (levels) of adiponectin in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerotic plaque, obesity, hypertension and disorder of lipid metabolism
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.59 Pain Relevance 0
Adiponectin, known to correlate with endothelial function and vascular health, is exclusively expressed in adipose tissue and abundant in human plasma, and appears to be decreased in individuals with obesity and type 2 diabetes, risk factors for atherosclerosis[19].
Negative_regulation (decreased) of Gene_expression (expressed) of Adiponectin in adipose tissue associated with diabetes mellitus, obesity and increased venous pressure under development
4) Confidence 0.31 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 1.39 Pain Relevance 0
Predictive values of HOMA, adiponectin and the EuroSCORE
Negative_regulation (Predictive) of Gene_expression (values) of adiponectin
5) Confidence 0.26 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 0.59 Pain Relevance 0
Plasma adiponectin levels were found to be lower in patients with many cancers, especially in upper gastric cancers, compared with those in the normal controls.
Negative_regulation (lower) of Gene_expression (levels) of adiponectin in upper associated with cancer and stomach cancer
6) Confidence 0.21 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2775732 Disease Relevance 1.75 Pain Relevance 0
A reduction of EAT may result in a reduced adiponectin production that has shown to exert protective effects under ischemic conditions [19].
Negative_regulation (reduced) of Gene_expression (production) of adiponectin associated with obesity
7) Confidence 0.16 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.51 Pain Relevance 0

General Comments

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