INT263019

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 4.14
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (DEFA6) extracellular region (DEFA6)
Anatomy Link Frequency
Paneth cells 1
bowel 1
Eustachian tube 1
DEFA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 5 99.02 Very High Very High Very High
Inflammation 173 98.92 Very High Very High Very High
cytokine 44 95.64 Very High Very High Very High
corticosteroid 5 91.20 High High
Crohn's disease 101 88.00 High High
fibrosis 5 50.76 Quite High
psoriasis 55 50.00 Quite Low
spastic colon 5 9.52 Low Low
Bile 30 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 38 99.64 Very High Very High Very High
Inflammatory Bowel Disease 100 98.92 Very High Very High Very High
Infection 139 97.16 Very High Very High Very High
INFLAMMATION 163 94.72 High High
Skin Diseases 5 93.68 High High
Ileitis 5 91.72 High High
Targeted Disruption 30 91.32 High High
Pouchitis 5 89.80 High High
Disease 220 88.00 High High
Sprains And Strains 23 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with the anti-TNF antibody infliximab was reportedly associated with normalization of defensin mRNA expression [77], but this was interpreted as a general effect stemming from epithelial regeneration.
Gene_expression (expression) of defensin mRNA associated with infliximab
1) Confidence 0.25 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.57 Pain Relevance 0.20
-defensin mRNA expression in biopsy specimens of ileal Crohn's patients, which was even more pronounced in patients carrying NOD2 mutations [58, 59], was observed.
Gene_expression (expression) of defensin mRNA
2) Confidence 0.25 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.79 Pain Relevance 0.23
-defensin mRNA expression is a primary effect.
Gene_expression (expression) of defensin mRNA
3) Confidence 0.22 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.70 Pain Relevance 0.18
-defensins includes human neutrophil peptides 1–4 (HNP1–4) produced by granulocytes and human defensin 5 and 6 (HD5 and HD6) produced by Paneth cells.
Gene_expression (produced) of defensin 5 and 6 in Paneth cells
4) Confidence 0.22 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.28 Pain Relevance 0.09
Different defensin mRNA expression in the different forms of inflammatory bowel diseases has been noted, as in patients with ulcerative colitis, hBD-2 and hBD-3 are strongly induced in the event of inflammation.
Gene_expression (expression) of defensin mRNA in bowel associated with inflammatory bowel disease and inflammation
5) Confidence 0.19 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 1.07 Pain Relevance 0.43
Genotyping of defensin copy number
Gene_expression (Genotyping) of defensin
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.19 Pain Relevance 0.05
To demonstrate the net collateral effect that RSV-induced, altered expression of this defensin had on the bacterial load present in the URT, we used a polymicrobial infection model to demonstrate that RSV challenge prior to inoculation with NTHI resulted in a consistent increase in the concentration of NTHI, recoverable in nasopharyngeal lavage fluids, compared with a mock-challenged cohort.
Gene_expression (expression) of defensin associated with infection and respiratory syncytial virus
7) Confidence 0.01 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 0.48 Pain Relevance 0
Heavier expression of a defensin at the proximal end of the Eustachian tube could thus serve to maintain the bacterial load at a colonizing, as opposed to infectious, level, thereby contributing to the diverse mechanisms by which the Eustachian tube defends the middle ear.
Gene_expression (expression) of defensin in Eustachian tube
8) Confidence 0.01 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox