INT263024

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 1
DEFB104A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 19 99.84 Very High Very High Very High
psoriasis 50 81.76 Quite High
Inflammation 14 63.40 Quite High
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 69 97.38 Very High Very High Very High
Eczema 19 76.40 Quite High
Infection 2 67.44 Quite High
INFLAMMATION 14 63.40 Quite High
Viral Infection 1 60.48 Quite High
Disease 38 50.00 Quite Low
Skin Diseases 5 33.60 Quite Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the eight beta-defensin genes located on 8p23.1, human beta-defensin-1 (hBD-1) protein, (encoded by DEFB1) and hBD-3 (encoded by DEFB103) are constitutively expressed at low levels in skin [24]. hBD-2 (encoded by DEFB4) is not expressed in normal skin but is highly expressed in psoriatic skin. hBD-4 (encoded by DEFB104) is less well characterized at the protein level but is found in skin by RT-PCR. hBD-2, hBD-3 and hBD-4 can be induced by cytokines and bacterial lipopolysaccharides in various epithelial cell types [25].
Positive_regulation (induced) of hBD-4 in skin associated with psoriasis and cytokine
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.57 Pain Relevance 0.18

General Comments

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