INT263027

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.89
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB103A)
Anatomy Link Frequency
colon 1
skin 1
bowel 1
Paneth cells 1
cavity 1
DEFB103A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 99.84 Very High Very High Very High
Inflammation 81 99.68 Very High Very High Very High
Crohn's disease 41 93.84 High High
psoriasis 52 81.76 Quite High
cINOD 15 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
diclofenac 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 16 100.00 Very High Very High Very High
Inflammatory Bowel Disease 40 99.76 Very High Very High Very High
INFLAMMATION 75 99.68 Very High Very High Very High
Infection 30 99.04 Very High Very High Very High
Psoriasis 71 97.58 Very High Very High Very High
Disease 104 93.20 High High
Sprains And Strains 6 85.12 High High
Eczema 21 76.40 Quite High
Viral Infection 1 60.48 Quite High
Burns 29 55.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the healthy colon, hBD-2 and hBD-3 are absent and only induced during inflammation or infection.
Positive_regulation (induced) of hBD-3 in colon associated with inflammation and infection
1) Confidence 0.45 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.83 Pain Relevance 0.29
Different defensin mRNA expression in the different forms of inflammatory bowel diseases has been noted, as in patients with ulcerative colitis, hBD-2 and hBD-3 are strongly induced in the event of inflammation.
Positive_regulation (induced) of hBD-3 in bowel associated with inflammatory bowel disease and inflammation
2) Confidence 0.45 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 1.11 Pain Relevance 0.45
Of the eight beta-defensin genes located on 8p23.1, human beta-defensin-1 (hBD-1) protein, (encoded by DEFB1) and hBD-3 (encoded by DEFB103) are constitutively expressed at low levels in skin [24]. hBD-2 (encoded by DEFB4) is not expressed in normal skin but is highly expressed in psoriatic skin. hBD-4 (encoded by DEFB104) is less well characterized at the protein level but is found in skin by RT-PCR. hBD-2, hBD-3 and hBD-4 can be induced by cytokines and bacterial lipopolysaccharides in various epithelial cell types [25].
Positive_regulation (induced) of hBD-3 in skin associated with psoriasis and cytokine
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.57 Pain Relevance 0.18
Certain epithelial defensins are constitutively expressed (HBD-1), whereas others are induced after tissue injury or exposure to microbes (HBD-2, HBD-3, and HNP-1).13 Paneth cells are a major source of ?
Positive_regulation (induced) of HBD-3 in Paneth cells associated with injury
4) Confidence 0.20 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.38 Pain Relevance 0
For the arylideneaminoxy-derivative compounds 5–14, the Gold program predicted the typical thyroxine orientation (forward binding mode) using the Goldscore functions; The aromatic ring is inserted into HBP3, and the ?
Positive_regulation (inserted) of HBP3
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0 Pain Relevance 0
The trifluoromethyl substituent occupies halogen binding pocket 3 (HBP3) in the inner cavity.
Positive_regulation (occupies) of HBP3 in cavity
6) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709434 Disease Relevance 0 Pain Relevance 0

General Comments

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