INT263046

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.98
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
brain 2
endometrium 2
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 156 100.00 Very High Very High Very High
fibrosis 59 99.50 Very High Very High Very High
endometriosis 168 97.92 Very High Very High Very High
Spinal cord 22 80.76 Quite High
Demyelination 6 80.24 Quite High
Inflammation 71 76.64 Quite High
cytokine 41 62.88 Quite High
Peripheral nervous system 4 42.40 Quite Low
Nerve growth factor 24 34.64 Quite Low
Central nervous system 12 32.72 Quite Low
Disease Link Frequency Relevance Heat
Breast Cancer 3 99.84 Very High Very High Very High
Fibrosis 38 99.50 Very High Very High Very High
Metastasis 3 99.04 Very High Very High Very High
Glioma 72 98.84 Very High Very High Very High
Cancer 138 98.20 Very High Very High Very High
Endometriosis 224 97.92 Very High Very High Very High
Immunization 15 97.36 Very High Very High Very High
Dilated Cardiomyopathy 2 95.52 Very High Very High Very High
Injury 58 93.80 High High
Disease 38 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the 14th day when fibrosis progressed, the overall expression of the MMP-2 and MMP-9 was very low.
Negative_regulation (low) of Gene_expression (expression) of MMP-2 associated with fibrosis and metalloproteinase
1) Confidence 0.34 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.94 Pain Relevance 0.87
Zhou et al found increased MMP2 expression and activity in their ?
Negative_regulation (found) of Gene_expression (expression) of MMP2
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.49 Pain Relevance 0.18
Recent studies have shown that ERK-specific inhibitors cause a decrease in the expression of MMP2 in breast cancer brain metastases [35].
Negative_regulation (decrease) of Gene_expression (expression) of MMP2 in brain associated with breast cancer and metastasis
3) Confidence 0.25 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.90 Pain Relevance 0
In addition, the decrease in ERK1 and ERK2 expression could be directly linked to decreased MMP2 expression and proteolytic activity in the GLA treated tumours.
Negative_regulation (decreased) of Gene_expression (expression) of MMP2 associated with cancer
4) Confidence 0.25 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.78 Pain Relevance 0
The presence of GLA caused inhibition of mRNA expression of VEGF, Flt1, ERK1/2 and MMP2 but not Flk1.
Negative_regulation (inhibition) of Gene_expression (expression) of MMP2
5) Confidence 0.25 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.80 Pain Relevance 0
This has been attributed to the decreased expression of MMP-2.
Negative_regulation (decreased) of Gene_expression (expression) of MMP-2 associated with metalloproteinase
6) Confidence 0.09 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 1.10 Pain Relevance 0.33
In contrast, another study reported MMP-1 and MMP-2 to be highly expressed in eutopic but not ectopic endometrium of women with endometriosis and a decrease in the MMP-2 inhibitor (TIMP-2) [98], suggesting a role of MMP in the very early development of the disease.
Negative_regulation (reported) of Gene_expression (expressed) of MMP-2 in endometrium associated with endometriosis, metalloproteinase and disease
7) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.97 Pain Relevance 0.71

General Comments

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