INT263048

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1, Mmp2) cytoplasm (Tgfb1, Mmp2) extracellular space (Tgfb1, Mmp2)
extracellular region (Tgfb1, Mmp2) proteinaceous extracellular matrix (Tgfb1, Mmp2) nucleus (Tgfb1, Mmp2)
Anatomy Link Frequency
epithelial cells 2
Tgfb1 (Rattus norvegicus)
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 122 100.00 Very High Very High Very High
fibrosis 40 99.34 Very High Very High Very High
cytokine 7 96.12 Very High Very High Very High
Inflammation 23 86.16 High High
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 28 99.34 Very High Very High Very High
Fibrosis 23 87.64 High High
INFLAMMATION 22 86.16 High High
Pneumonia 1 66.28 Quite High
Injury 8 46.84 Quite Low
Edema 5 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGF-beta 1, the most potent fibrogenic cytokine, has been reported to increase in pulmonary fibrosis and to be expressed in alveolar epithelial cells in higher levels even in later phase of pulmonary fibrosis.37,38 It was also reported that TGF-beta 1 induces transition of alveolar epithelial cells to mesenchymal/fibroblasts-like cells and MMP-2 expression in those cells,39 possibly suggesting that MMP-2 production in alveolar epithelial cells by TGF-beta 1 may promote pulmonary fibrosis.
TGF-beta 1 Positive_regulation (induces) of Gene_expression (expression) of MMP-2 in epithelial cells associated with fibrosis, metalloproteinase, pulmonary fibrosis and cytokine
1) Confidence 0.13 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.81 Pain Relevance 1.07

General Comments

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