INT263053

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.60
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ERC1) cytoplasm (ERC1)
Anatomy Link Frequency
plasma 1
ERC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 327 100.00 Very High Very High Very High
Multiple sclerosis 3 97.96 Very High Very High Very High
Neurotransmitter 2 35.44 Quite Low
adenocard 2 31.84 Quite Low
antagonist 2 31.32 Quite Low
sodium channel 4 26.00 Quite Low
depression 17 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
intrathecal 9 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 35 99.36 Very High Very High Very High
Multiple Sclerosis 8 97.96 Very High Very High Very High
Infection 84 97.88 Very High Very High Very High
Targeted Disruption 4 53.60 Quite High
Manic Depressive Disorder 118 51.84 Quite High
Dengue 11 50.00 Quite Low
Cognitive Disorder 3 37.28 Quite Low
Epilepsy 20 32.40 Quite Low
Recurrence 19 5.00 Very Low Very Low Very Low
Aplastic Anemia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a single 200-mg dose of CBZ-ERC, peak plasma CBZ concentration was found to be 1.9 ± 0.3 ?
Gene_expression (dose) of ERC in plasma associated with carbamazepine
1) Confidence 0.65 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671727 Disease Relevance 0 Pain Relevance 0.58
Subgroup analyses of the pooled data from these two pivotal studies showed that CBZ-ERC reduced both manic and depressive symptoms.
Gene_expression (reduced) of ERC associated with depression and carbamazepine
2) Confidence 0.65 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671727 Disease Relevance 0.29 Pain Relevance 0.37
These human genes include early endosome antigen 1 (EEA1; 72%), Rab6 interacting protein 2 (ELKS; 63%) and ATPase (ATP6V0A1; 77%).
Gene_expression (include) of Rab6 interacting protein 2
3) Confidence 0.32 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.21 Pain Relevance 0
In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally.
Gene_expression (production) of ERC associated with multiple sclerosis
4) Confidence 0.19 Published 2009 Journal J Transl Med Section Abstract Doc Link PMC2649897 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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