INT263065

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 19
Disease Relevance 3.01
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Kncn) biological_process (Kncn) cytoplasm (Kncn)
Anatomy Link Frequency
neuronal 4
dendrite 1
neuron 1
transverse process 1
crest 1
Kncn (Mus musculus)
Pain Link Frequency Relevance Heat
Somatosensory cortex 672 99.72 Very High Very High Very High
allodynia 45 99.04 Very High Very High Very High
Eae 78 98.78 Very High Very High Very High
dorsal root ganglion 54 98.52 Very High Very High Very High
Brush evoked pain 63 94.64 High High
isoflurane 3 88.24 High High
Pain 198 87.12 High High
Glutamate 112 84.32 Quite High
primary somatosensory cortex 48 78.12 Quite High
Action potential 192 76.88 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 384 99.48 Very High Very High Very High
Neuropathic Pain 186 99.04 Very High Very High Very High
Ganglion Cysts 63 98.52 Very High Very High Very High
Pain 213 87.12 High High
Neuroma 18 68.60 Quite High
Nervous System Injury 57 64.56 Quite High
INFLAMMATION 6 55.92 Quite High
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, because in vS1 the L5A is thin (Table 1) and both L5A and L5B are low in neuronal density (Figure S4), the projections to and from L5, such as L5A?
Gene_expression (low) of L5A in neuronal
1) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0
Another prominent projection was from L2 and L3 to L5A and L5B; inputs originating in more superficial regions of L2/3 targeted relatively more superficial regions of L5A/L5B (note the diagonal shape of the L2/3?
Gene_expression (regions) of L5A
2) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
For example, because in vS1 the L5A is thin (Table 1) and both L5A and L5B are low in neuronal density (Figure S4), the projections to and from L5, such as L5A?
Gene_expression (thin) of L5A in neuronal
3) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
Another prominent projection was from L2 and L3 to L5A and L5B; inputs originating in more superficial regions of L2/3 targeted relatively more superficial regions of L5A/L5B (note the diagonal shape of the L2/3?
Gene_expression (/) of L5A
4) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
For example, because in vS1 the L5A is thin (Table 1) and both L5A and L5B are low in neuronal density (Figure S4), the projections to and from L5, such as L5A?
Gene_expression (projections) of L5A in neuronal
5) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0
Although not as strong at the single cell level, the entire L6 excited L5B as much as L3 (Figure 7I).
Gene_expression (excited) of L5B
6) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.12
For example, because in vS1 the L5A is thin (Table 1) and both L5A and L5B are low in neuronal density (Figure S4), the projections to and from L5, such as L5A?
Gene_expression (low) of L5B in neuronal
7) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0
Weaker ascending projections, within L5 and L5A?
Gene_expression (within) of L5
8) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0
Another prominent projection was from L2 and L3 to L5A and L5B; inputs originating in more superficial regions of L2/3 targeted relatively more superficial regions of L5A/L5B (note the diagonal shape of the L2/3?
Gene_expression (regions) of L5B
9) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
Another prominent projection was from L2 and L3 to L5A and L5B; inputs originating in more superficial regions of L2/3 targeted relatively more superficial regions of L5A/L5B (note the diagonal shape of the L2/3?
Gene_expression (/) of L5B
10) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
L5B connection was stronger than L4?
Gene_expression (connection) of L5B
11) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.04
Weaker ascending projections, within L5 and L5A?
Gene_expression (within) of L5A
12) Confidence 0.34 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0
L5 projection identified in S2 was more than twice as strong at the neuron?
Gene_expression (projection) of L5 in neuron associated with somatosensory cortex
13) Confidence 0.29 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.13
The superficial layers L2/3 and L5A are compressed, and deeper layers L5B and L6 are expanded, consistent with vM1's location at the crest of a cortical convexity [28].
Gene_expression (compressed) of L5A in crest
14) Confidence 0.29 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.04
Both superficial and deep L5 neurons had dense basal dendrites and a single apical dendrite extending to L1, and L6 neurons had apical dendrites that did not extend to L1; in some cases, these were inverted pyramids (Figure 3A).
Gene_expression (neurons) of L5 in dendrite
15) Confidence 0.29 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
L5 exceeded the strength of the ascending L4?
Gene_expression (exceeded) of L5
16) Confidence 0.29 Published 2011 Journal PLoS Biology Section Abstract Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.21
In addition we plotted the degree of allodynia against the absolute signal intensity for gene expression in the axotomized L5DRGs.
Gene_expression (expression) of L5DRGs associated with allodynia
17) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.84 Pain Relevance 0.43
Rather than averaging over all SNL operated animals in a given strain, fold regulation of gene expression in the ipsilateral L5 and L4 DRGs was calculated for each DRG, in each individual mouse, in each strain.
Gene_expression (expression) of L5 associated with dorsal root ganglion, eae and sprains and strains
18) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.32 Pain Relevance 0.47
The L6 transverse process was then removed exposing the L5 spinal nerve.
Gene_expression (exposing) of L5 in transverse process
19) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.85 Pain Relevance 0.56

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