INT263088

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 2.13
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) molecular_function (Mki67) cellular_component (Mki67)
Anatomy Link Frequency
retina 2
hepatocytes 1
liver 1
Mki67 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 168 99.98 Very High Very High Very High
fluoxetine 130 99.98 Very High Very High Very High
amygdala 118 97.88 Very High Very High Very High
depression 32 94.60 High High
cva 10 55.92 Quite High
antidepressant 31 50.00 Quite Low
cytokine 31 23.04 Low Low
imagery 37 23.00 Low Low
GABA receptor 28 18.48 Low Low
anesthesia 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 128 99.48 Very High Very High Very High
Breast Cancer 1 97.56 Very High Very High Very High
Cancer 10 94.68 High High
Depression 33 94.60 High High
Anxiety Disorder 91 80.84 Quite High
Body Weight 19 67.04 Quite High
Neurodegenerative Disease 54 64.32 Quite High
Hemorrhage 10 55.92 Quite High
Aging 7 53.84 Quite High
Death 37 53.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One week after hepatectomy, hepatocytes showed increased expression of PCNA in all groups (p < 0.01), while Ki-67 was increased only in the EPO treatment group (p < 0.01).
Positive_regulation (increased) of Ki-67 in hepatocytes
1) Confidence 0.19 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.06 Pain Relevance 0
On postoperative day 3 all rats had increased Ki 67 (p < 0.05).
Positive_regulation (increased) of Ki 67
2) Confidence 0.13 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
The increase in Ki-67 index suggested the precancerous status of liver of rats treated by 2,4-DAT (Table 1, Fig. 1).
Positive_regulation (increase) of Ki-67 in liver
3) Confidence 0.13 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.33 Pain Relevance 0
An unexpected finding of this study was the observation that when more than one lesion was made, Ki67 upregulation was found across the entire retina.
Positive_regulation (upregulation) of Ki67 in retina
4) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0.11 Pain Relevance 0
Lesions were targeted at peripheral and central locations and assessed 72 h later for the upregulation of the cell-cycle marker Ki67, and subsequently with BrdU, to reveal patterns of cell production.
Positive_regulation (upregulation) of Ki67
5) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0.05 Pain Relevance 0
This resulted in Ki67 upregulation in both central and peripheral areas, more than doubling the number normally found in the periphery and lifting levels in the center to approximately the number found in the normal nonlesioned peripheral retina.
Positive_regulation (upregulation) of Ki67 in retina
6) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
Irrespective of location, all lesions were associated with an upregulation of Ki67-positive cells in the RPE sheet.
Positive_regulation (upregulation) of Ki67
7) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
To reveal the relative influence of central and peripheral lesions on Ki67 upregulation in local and distant labeling patterns, single and multiple lesions were placed in these different locations in four groups of animals (Figure 4).
Positive_regulation (upregulation) of Ki67
8) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
In all postoperative days, the combination of EPO and GM-CSF failed to increase PCNA and Ki 67 staining to the extent that EPO alone did (p < 0.01).
Neg (failed) Positive_regulation (increase) of Ki 67
9) Confidence 0.06 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.18 Pain Relevance 0.03
Hence, unexpectedly, lesions increased Ki67 labeling pan retinally.
Positive_regulation (increased) of Ki67
10) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
Bicuculline did not affect the total number of Ki-67-positive cells (61.72±3.50), however, it significantly decreased GABA-mediated increases in Ki-67-positive cells (60.44±1.95).
Positive_regulation (increases) of Ki-67 associated with gaba
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0 Pain Relevance 0.33
The administration of GABA increased Ki-67-positive cells to 77.11±4.83.
Positive_regulation (increased) of Ki-67 associated with gaba
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0 Pain Relevance 0.30
The same size lesion placed in the periphery resulted in a very substantial increase in the number of Ki67-positive cells in peripheral regions but also upregulated numbers in the center, although to a level less than that found following a single central lesion.
Positive_regulation (increase) of Ki67
13) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
Fluoxetine increased Ki67 labeling (F(1,16)=7.8, P?
Positive_regulation (increased) of Ki67 associated with fluoxetine
14) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2650100 Disease Relevance 0.51 Pain Relevance 0.53
Pairwise comparisons showed that while fluoxetine stimulated Ki67 in control-implanted rats (Bonferroni, P=0.003) this was not observed in corticosterone-treated ones (P>0.05) (Fig. 4).


Positive_regulation (stimulated) of Ki67 associated with fluoxetine
15) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2650100 Disease Relevance 0.48 Pain Relevance 0.51
A first ANOVA on cell proliferation data as indicated by the number of Ki67-IR cells in the DG, revealed a significant increase in Ki67-IR cells with fluoxetine (p<0.01), but no effect of BLA lesions (n.s.), and no significant interaction between the two factors (n.s.)
Positive_regulation (increase) of Ki67 associated with amygdala and fluoxetine
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0.41 Pain Relevance 0.88

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