INT263089

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.82
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) molecular_function (Mki67) cellular_component (Mki67)
Anatomy Link Frequency
Ki67 2
Mki67 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 96 99.98 Very High Very High Very High
gABA 84 92.20 High High
cva 4 75.52 Quite High
GABA receptor 14 73.68 Quite High
Calcium channel 1 55.92 Quite High
amygdala 118 50.00 Quite Low
depression 32 50.00 Quite Low
antidepressant 31 50.00 Quite Low
cytokine 32 42.64 Quite Low
anesthesia 10 15.32 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 54 99.48 Very High Very High Very High
Body Weight 14 86.64 High High
Hemorrhage 4 75.52 Quite High
Postoperative Complications 4 73.36 Quite High
Depression 33 50.00 Quite Low
Neurodegenerative Disease 39 42.72 Quite Low
Exsanguination 8 37.84 Quite Low
Cirrhosis 4 32.28 Quite Low
Stress 9 25.40 Quite Low
Sepsis 4 19.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is noted even before any "triggering" for regeneration took place, as rats pre-treated with rhEPO showed increased expression of both Ki 67 and PCNA before hepatectomy was performed.
Positive_regulation (increased) of Gene_expression (expression) of Ki 67
1) Confidence 0.14 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.08 Pain Relevance 0
In addition both Ki 67 and PCNA expression were significantly increased in EPO compared to GM-CSF treated animals in all post-operative days (p < 0.01).
Positive_regulation (increased) of Gene_expression (expression) of Ki 67
2) Confidence 0.14 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.24 Pain Relevance 0.04
EPO pretreatment increased Ki 67 and PCNA expression preoperatively (p < 0.01).
Positive_regulation (increased) of Gene_expression (expression) of Ki 67
3) Confidence 0.13 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
On postoperative day 1 all rats had increased Ki 67 and PCNA expression (p < 0.05).


Positive_regulation (increased) of Gene_expression (expression) of Ki 67
4) Confidence 0.13 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
The increased expression of nuclear antigen protein, Ki-67 is an indication of proliferation since it is not expressed in resting cells.
Positive_regulation (increased) of Gene_expression (expression) of Ki-67
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0 Pain Relevance 0.35
Fluoxetine increased Ki67 labeling (F(1,16)=7.8, P?
Positive_regulation (increased) of Gene_expression (labeling) of Ki67 associated with fluoxetine
6) Confidence 0.04 Published 2008 Journal Neuroscience Section Body Doc Link PMC2650100 Disease Relevance 0.51 Pain Relevance 0.53
After washing in PBS, sections for Ki67 were incubated for 120 minutes with donkey anti-mouse IgG, (1?
Positive_regulation (incubated) of Gene_expression (sections) of Ki67 in Ki67
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0 Pain Relevance 0

General Comments

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