INT26310

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Context Info
Confidence 0.18
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, ACE2) extracellular region (IL1B, ACE2) aging (IL1B)
cell-cell signaling (IL1B) cytosol (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
cartilage 1
IL1B (Homo sapiens)
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 4 99.24 Very High Very High Very High
INFLAMMATION 1 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro IL-1 was found to significantly increase the catabolism of proteoglycan macromolecules and to stimulate the metalloprotease activity in human OA cartilage explants.
IL-1 Positive_regulation (stimulate) of metalloprotease in cartilage associated with osteoarthritis
1) Confidence 0.18 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2553967 Disease Relevance 0.46 Pain Relevance 0.07

General Comments

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