INT263121

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 38 81.48 Quite High
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
backache 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 1 98.08 Very High Very High Very High
Hypertension 5 97.44 Very High Very High Very High
Pulmonary Disease 31 94.96 High High
INFLAMMATION 44 81.48 Quite High
Increased Venous Pressure Under Development 6 75.68 Quite High
Apoptosis 1 71.20 Quite High
Asthma 2 69.60 Quite High
Disease 6 62.16 Quite High
Reprotox - General 2 64 58.48 Quite High
Vomiting 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the patients, the factors most significantly associated with treatment preference were differences in time concerns, choice of dose, intercourse satisfaction, number of sexual attempts, satisfaction with erection hardness and the absence of or only minor side effects.19 Although preference studies have shown that all the PDE5 inhibitors were highly effective, the majority of patients seemed to prefer tadalafil because it is easier to take, can be ingested at any time of the day, and its property of enabling them to achieve an erection, with sexual stimulation, long after taking the drug (eg, 8, 16 or 24 hours later), leading to higher sexual self-confidence and spontaneity and fewer time concerns related to sexual encounters.7,19
Negative_regulation (effective) of Negative_regulation (inhibitors) of PDE5
1) Confidence 0.43 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778425 Disease Relevance 0.11 Pain Relevance 0
Selective PDE3 inhibitors promote bronchodilatation in humans (Leeman et al 1987; Fujimura et al 1995; Myou et al 1999) and inhibition of PDE5 with sildenafil reduces pulmonary vascular resistance in subjects with hypoxic-induced pulmonary hypertension and in patients with severe pulmonary hypertension (Zhao et al 2001; Ghofrani et al 2004; Sastry et al 2004).
Negative_regulation (reduces) of Negative_regulation (inhibition) of PDE5 associated with hypoxia and hypertension
2) Confidence 0.10 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 1.22 Pain Relevance 0.14

General Comments

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