INT263128

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
Anatomy Link Frequency
B-cell 2
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 76 92.64 High High
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 98.32 Very High Very High Very High
Cancer 33 95.80 Very High Very High Very High
Hodgkin's Disease 8 94.96 High High
INFLAMMATION 88 92.64 High High
Acromegaly 8 85.56 High High
Reprotox - General 2 4 70.64 Quite High
Obesity 4 62.44 Quite High
Lymphatic System Cancer 5 57.04 Quite High
Adrenal Cancer 10 33.92 Quite Low
Thyroid Neoplasm 2 14.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Siguazodan, a PDE3 inhibitor, potentiated relaxation induced by rolipram suggesting an interaction between PDE3 inhibition and PDE4 inhibition (Torphy et al 1993).
Negative_regulation (inhibition) of PDE4 Binding (interaction) of
1) Confidence 0.22 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.31 Pain Relevance 0.09
Siguazodan, a PDE3 inhibitor, potentiated relaxation induced by rolipram suggesting an interaction between PDE3 inhibition and PDE4 inhibition (Torphy et al 1993).
Negative_regulation (inhibition) of PDE4 Binding (interaction) of
2) Confidence 0.22 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.31 Pain Relevance 0.09
The R81X is a known functional mutation that codes for a truncated protein lacking the tetratricopeptide repeat (TPR) carboxy terminal domains, which are essential for AIP to bind to the aryl hydrocarbon receptor (AHR) and heat shock 90 (HSP90).12,27 Previous in vitro studies of the R81X mutation have shown that it blocks the interaction of wild type AIP and phosphodiesterase type 4A (PDE4A), potentially disrupting the cAMP cascade.28

AIP somatic status in the somatotropinoma, adrenocortical tumor and B-cell non-Hodgkin lymphoma

Negative_regulation (blocks) of PDE4A Binding (interaction) of in B-cell associated with cancer, shock and hodgkin's disease
3) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.71 Pain Relevance 0

General Comments

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