INT263129

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.92
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 91 99.62 Very High Very High Very High
headache 3 97.60 Very High Very High Very High
fibrosis 2 89.40 High High
Inflammatory mediators 9 81.36 Quite High
cINOD 2 61.52 Quite High
adenocard 6 58.36 Quite High
psoriasis 4 51.04 Quite High
chemokine 2 41.36 Quite Low
cytokine 7 40.88 Quite Low
Arthritis 47 37.52 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 104 99.62 Very High Very High Very High
Myocardial Infarction 1 98.64 Very High Very High Very High
Diarrhoea 5 98.04 Very High Very High Very High
Headache 3 97.60 Very High Very High Very High
Vomiting 14 95.72 Very High Very High Very High
Adhesions 2 91.48 High High
Pulmonary Disease 67 90.28 High High
Fibrosis 2 89.40 High High
Asthma 5 83.44 Quite High
Necrosis 5 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A novel PDE4 inhibitor, apremilast has recently been generated [17] which has a half maximal inhibitory concentration (IC50) of 74 nM and inhibits TNF?
Positive_regulation (generated) of Negative_regulation (inhibitor) of PDE4
1) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911898 Disease Relevance 1.18 Pain Relevance 0.31
Inhibition of PDE4 increases intracellular cAMP concentrations which ultimately results in reduction of cellular inflammatory activity.
Positive_regulation (increases) of Negative_regulation (Inhibition) of PDE4 associated with inflammation
2) Confidence 0.26 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 1.27 Pain Relevance 0.35
In this way the anti-inflammatory properties may be augmented whilst reducing PDE4 related side-effects in other organs.
Positive_regulation (augmented) of Negative_regulation (reducing) of PDE4 associated with inflammation
3) Confidence 0.26 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.47 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox