INT263130

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 3 88.44 High High
Inflammation 39 65.28 Quite High
GABAergic 3 26.48 Quite Low
addiction 2 14.16 Low Low
ischemia 3 13.40 Low Low
tolerance 3 12.80 Low Low
depression 3 12.64 Low Low
agonist 16 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 111 84.56 Quite High
Endometriosis (extended) 3 78.72 Quite High
Dementia 14 71.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 65.44 Quite High
INFLAMMATION 45 65.28 Quite High
Targeted Disruption 2 51.44 Quite High
Toxicity 2 47.92 Quite Low
Anxiety Disorder 9 29.60 Quite Low
Aging 3 29.04 Quite Low
Pulmonary Disease 31 24.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All isoforms of PDE4 can be phosphorylated by ERK, but the effects of this on PDE4 activity depend on the presence of UCR1.
Phosphorylation (phosphorylated) of PDE4
1) Confidence 0.42 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.18 Pain Relevance 0.06
This opens new perspectives for a more mechanistic approach to the cellular signaling pathways of memory, for example with the use of phosphodiesterase IV inhibitors increasing CREB phosphorylation (Nagakura et al 2002; Tully et al 2003).
Phosphorylation (phosphorylation) of phosphodiesterase IV
2) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654526 Disease Relevance 0.49 Pain Relevance 0.04

General Comments

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