INT263134

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE3A) signal transduction (PDE3A) lipid metabolic process (PDE3A)
PDE3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 114 90.16 High High
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 6 96.12 Very High Very High Very High
INFLAMMATION 132 90.16 High High
Reprotox - General 2 6 68.16 Quite High
Pulmonary Disease 93 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Hypertension 15 5.00 Very Low Very Low Very Low
Vomiting 15 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Nicotine Addiction 9 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NHR1 contains transmembrane helices, whereas NHR2 appears to be involved in the binding of PDE3 to other currently unidentified proteins.
PDE3 Binding (binding) of
1) Confidence 0.15 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.07 Pain Relevance 0
Siguazodan, a PDE3 inhibitor, potentiated relaxation induced by rolipram suggesting an interaction between PDE3 inhibition and PDE4 inhibition (Torphy et al 1993).
PDE3 Binding (interaction) of
2) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.31 Pain Relevance 0.09
It has recently been shown that phosphorylation allows the binding of 14-3-3 proteins to PDE3 (Figure 2) (Pozuelo Rubio et al 2005).
PDE3 Binding (binding) of
3) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.10 Pain Relevance 0

General Comments

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