INT263136

Context Info Confidence 0.21 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.19 Pain Relevance 0

cytosol (PDE3A) signal transduction (PDE3A) lipid metabolic process (PDE3A)

Anatomy Link Frequency platelets 3 adipocytes 1 PDE3A (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 76 5.00 Inflammatory mediators 8 5.00 adenocard 4 5.00 cytokine 2 5.00 cINOD 2 5.00 fibrosis 2 5.00 Inflammatory response 2 5.00 Neurotransmitter 2 5.00 abdominal pain 2 5.00 chemokine 2 5.00

Disease Link Frequency Relevance Heat Obesity 4 94.24 INFLAMMATION 88 5.00 Pulmonary Disease 62 5.00 Disease 12 5.00 Hypertension 10 5.00 Vomiting 10 5.00 Increased Venous Pressure Under Development 8 5.00 Nicotine Addiction 6 5.00 Hyperplasia 4 5.00 Natriuresis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Phosphorylation of PDE3 is important in activating PDE3 in response to a variety of extracellular signals in cardiac, vascular and airway smooth muscle, as well as a number of other cells, including adipocytes and platelets (Degerman et al 1997).

Positive_regulation (important) of Positive_regulation (activating) of PDE3 in platelets associated with obesity

1) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.09 Pain Relevance 0

Phosphorylation of PDE3 is important in activating PDE3 in response to a variety of extracellular signals in cardiac, vascular and airway smooth muscle, as well as a number of other cells, including adipocytes and platelets (Degerman et al 1997).

Positive_regulation (important) of in adipocytes Positive_regulation (activating) of PDE3 in platelets associated with obesity

2) Confidence 0.07 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.09 Pain Relevance 0

General Comments

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