INT263138

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.13
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ZAK) cell proliferation (ZAK) cell death (ZAK)
nucleus (ZAK) cell cycle (ZAK) response to stress (ZAK)
ZAK (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 88.40 High High
agonist 194 86.44 High High
Angina 4 10.24 Low Low
Inflammation 76 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
b2 receptor 2 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 4 76.08 Quite High
Atherosclerosis 6 22.48 Low Low
Hypertension 22 20.88 Low Low
Thrombosis 10 20.32 Low Low
Renal Disease 2 12.44 Low Low
Asthma 6 10.96 Low Low
Cv General 3 Under Development 4 10.24 Low Low
Increased Venous Pressure Under Development 16 8.72 Low Low
Disease 16 8.48 Low Low
INFLAMMATION 88 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was directly impaired by prostacyclin and NO through protein kinase (PK)A- and PKG-dependent phosphorylation, respectively, signaling by TP?
Phosphorylation (phosphorylation) of PK
1) Confidence 0.17 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
, undergoes prostacyclin- induced desensitization mediated through direct cAMP-protein kinase (PK) A phosphorylation of TP?
Phosphorylation (phosphorylation) of PK
2) Confidence 0.16 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
In studies investigating heterologous desensitization or cross-talk between TXA2 and other prostanoids, it has been recently established that while both TP isoforms have evolved to share a similar mechanism of protein kinase (PK)C-induced phosphorylation in response to signalling by the EP1 subtype of the prostaglandin (PG) E2 receptor and by the PGF2?
Phosphorylation (phosphorylation) of PK
3) Confidence 0.10 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
, is subject to prostacyclin and PGD2-mediated desensitization in a mechanism involving direct protein kinase (PK) A phosphorylation of TP?
Phosphorylation (phosphorylation) of PK
4) Confidence 0.10 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.03
There are significant differences in the amino acid sequence of the N-terminal regions of PDE3A and PDE3B, but they both contain two hydrophobic regions involved in intracellular targeting termed N-terminal hydrophobic regions (“NHRs”) and sites for phosphorylation and activation by PK-B (Degerman et al 1997).
Phosphorylation (phosphorylation) of PK-B
5) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.06 Pain Relevance 0
The three regulatory phosphorylation sites which are phosphorylated by PK-B and PK-A lie between NHR1 and NHR2 (Rascon et al 1994; Kitamura et al 1999; Rondinone et al 2000).
Phosphorylation (phosphorylated) of PK-B
6) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.08 Pain Relevance 0

General Comments

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