INT26318

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.61
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD19)
Anatomy Link Frequency
B-cell 3
mature B cells 2
blast cells 1
T cells 1
CD19 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 53 97.40 Very High Very High Very High
cytokine 10 95.96 Very High Very High Very High
Multiple sclerosis 220 94.80 High High
imagery 61 92.24 High High
nud 1 90.24 High High
Inflammation 65 90.08 High High
abdominal pain 2 89.40 High High
Inflammatory response 5 85.76 High High
Pain 4 82.68 Quite High
intrathecal 29 81.76 Quite High
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 5 99.32 Very High Very High Very High
Neurological Disease 33 98.24 Very High Very High Very High
Demyelinating Disease 244 94.80 High High
Hematologic Neoplasms 1 94.48 High High
Syndrome 23 92.24 High High
Myeloid Leukemia 3 91.44 High High
Leukemia 14 91.24 High High
Disease 76 91.04 High High
Vomiting 7 90.80 High High
Encephalitis 12 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CP-690 550 30 mg BID was also associated with a mean increase in absolute CD19(+) B-lymphocytes of 130%.
Positive_regulation (increase) of CD19 in B-lymphocytes
1) Confidence 0.67 Published 2008 Journal Am. J. Transplant. Section Abstract Doc Link 18557720 Disease Relevance 0.45 Pain Relevance 0.17
Cell surface marker analysis of blast cells disclosed that they were positive for anti-HLA-DR, CD19, CD24, CD33 and CD38, but were negative for CD10 and CD20.
Positive_regulation (positive) of CD19 in blast cells
2) Confidence 0.55 Published 1989 Journal Rinsho Ketsueki Section Abstract Doc Link 2554012 Disease Relevance 0.58 Pain Relevance 0.12
We have found a statistically significant accumulation of CSF mature B cells (CD19+CD138?)
Positive_regulation (accumulation) of CD19 in mature B cells
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2438478 Disease Relevance 1.02 Pain Relevance 0.54
We report a statistically significant increase of CSF mature B cells (CD19+CD138?)
Positive_regulation (increase) of CD19 in mature B cells
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.72 Pain Relevance 0.57
Chronic lymphocytic leukemia (CLL) is characterized by the gradual accumulation of small mature B-cells, non proliferating cells and B-cell surface markers such as CD19, CD20 in addition to CD5 [32] in the patient.
Positive_regulation (accumulation) of CD19 in B-cell associated with chronic lymphoid leukemia
5) Confidence 0.25 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.73 Pain Relevance 0
Circulating CD19+ B-cell levels decreased (mean change from baseline ±50%) for at least 12 weeks after the last infusion.
Positive_regulation (Circulating) of CD19 in B-cell
6) Confidence 0.23 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.48 Pain Relevance 0.06
Decreases in CD4+ and CD8+ T cells, increases in CD19+ B cells, and no change in CD 64+ monocytes/macrophages were noted during the estriol treatment phase with a greater effect experienced by the RRMS patients.
Positive_regulation (increases) of CD19 in T cells associated with multiple sclerosis
7) Confidence 0.16 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.63 Pain Relevance 0.33

General Comments

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