INT263191

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pde1a) cytoplasm (Pde1a)
Anatomy Link Frequency
testis 4
brain 2
smooth muscle cells 1
Pde1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 229 13.28 Low Low
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
headache 11 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 33 96.96 Very High Very High Very High
Heart Rate Under Development 1 96.20 Very High Very High Very High
Diabetes Mellitus 16 69.20 Quite High
Hepatic Insufficiency 2 66.80 Quite High
Erectile Dysfunction 69 50.00 Quite Low
Pulmonary Disease 186 13.92 Low Low
INFLAMMATION 265 13.28 Low Low
Disease 46 5.00 Very Low Very Low Very Low
Hypertension 38 5.00 Very Low Very Low Very Low
Vomiting 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE1A1, PDE1A4, and PDE1A8 have the N2 terminal sequence and are widely expressed in lung and other tissues, whilst PDE1A5, PDE1A6, and PDE1A9 have the N1 sequence and are expressed in brain tissue and PDE1A10 and PDE1A11 which have the N3 sequence are expressed in testis (Michibata et al 2001).
Gene_expression (expressed) of PDE1A9 in testis
1) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
PDE1A1, PDE1A4, and PDE1A8 have the N2 terminal sequence and are widely expressed in lung and other tissues, whilst PDE1A5, PDE1A6, and PDE1A9 have the N1 sequence and are expressed in brain tissue and PDE1A10 and PDE1A11 which have the N3 sequence are expressed in testis (Michibata et al 2001).
Gene_expression (expressed) of PDE1A8 in brain
2) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
PDE1A1, PDE1A4, and PDE1A8 have the N2 terminal sequence and are widely expressed in lung and other tissues, whilst PDE1A5, PDE1A6, and PDE1A9 have the N1 sequence and are expressed in brain tissue and PDE1A10 and PDE1A11 which have the N3 sequence are expressed in testis (Michibata et al 2001).
Gene_expression (expressed) of PDE1A11 in testis
3) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
PDE1A1, PDE1A4, and PDE1A8 have the N2 terminal sequence and are widely expressed in lung and other tissues, whilst PDE1A5, PDE1A6, and PDE1A9 have the N1 sequence and are expressed in brain tissue and PDE1A10 and PDE1A11 which have the N3 sequence are expressed in testis (Michibata et al 2001).
Gene_expression (expressed) of PDE1A10 in testis
4) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
PDE1A1, PDE1A4, and PDE1A8 have the N2 terminal sequence and are widely expressed in lung and other tissues, whilst PDE1A5, PDE1A6, and PDE1A9 have the N1 sequence and are expressed in brain tissue and PDE1A10 and PDE1A11 which have the N3 sequence are expressed in testis (Michibata et al 2001).
Gene_expression (expressed) of PDE1A4 in brain
5) Confidence 0.17 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
PDE1A1, PDE1A4, and PDE1A8 have the N2 terminal sequence and are widely expressed in lung and other tissues, whilst PDE1A5, PDE1A6, and PDE1A9 have the N1 sequence and are expressed in brain tissue and PDE1A10 and PDE1A11 which have the N3 sequence are expressed in testis (Michibata et al 2001).
Gene_expression (expressed) of PDE1A6 in testis
6) Confidence 0.17 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
Tadalafil’s nonselectivity with respect to PDE1 (expressed in the brain, myocardium, and vascular smooth muscle cells), may result in vasodilatation and tachycardia (Bischoff 2004).
Gene_expression (expressed) of PDE1 in smooth muscle cells associated with heart rate under development and increased venous pressure under development
7) Confidence 0.01 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.33 Pain Relevance 0

General Comments

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