INT263205

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
neuronal 2
endothelial cells 2
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 99.40 Very High Very High Very High
Inflammation 30 55.64 Quite High
carrageenan induced 1 47.68 Quite Low
cytokine 2 38.64 Quite Low
Paracetamol 1 24.20 Low Low
corticosteroid 12 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 99.40 Very High Very High Very High
Pulmonary Disease 55 86.24 High High
Injury 4 83.76 Quite High
Coronary Heart Disease 1 69.16 Quite High
Increased Venous Pressure Under Development 2 65.04 Quite High
Stroke 1 63.28 Quite High
Myocardial Infarction 12 59.64 Quite High
INFLAMMATION 30 55.64 Quite High
Pleurisy 1 48.04 Quite Low
Stress 32 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the concentration of xanthine oxidase products (superoxide and uric acid) in the supernatant of endothelial cells cultured with elastase was significantly reduced by the addition of carbocisteine to the culture.
Negative_regulation (reduced) of Gene_expression (products) of xanthine oxidase in endothelial cells
1) Confidence 0.41 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650606 Disease Relevance 0.28 Pain Relevance 0.05
The effects were not seen in endothelial NOS deficient mice, suggesting a role for neuronal NOS preventing XO inhibition of cardiac excitation-contraction coupling.80 The finding that allopurinol is a potent myofilament Ca2+ sensitizer, particularly in the setting of ischemia, is thought to be due to the inhibition of basal XO production.
Negative_regulation (inhibition) of Gene_expression (production) of XO in neuronal associated with ischemia
2) Confidence 0.41 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.36 Pain Relevance 0.05

General Comments

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