INT263227

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkcg, Trpv4) transport (Trpv4) intracellular (Prkcg)
cilium (Trpv4) transmembrane transport (Trpv4) response to stress (Prkcg)
Anatomy Link Frequency
neurons 2
Prkcg (Rattus norvegicus)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 38 99.90 Very High Very High Very High
dorsal root ganglion 92 99.84 Very High Very High Very High
Spinal cord 16 95.28 Very High Very High Very High
Inflammation 12 93.00 High High
Hippocampus 10 88.84 High High
depression 8 86.32 High High
Pyramidal cell 6 76.44 Quite High
qutenza 16 73.84 Quite High
TRP channel 12 36.20 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 92 99.84 Very High Very High Very High
Hypersensitivity 4 94.00 High High
INFLAMMATION 12 93.00 High High
Depression 8 86.32 High High
Nociception 16 5.00 Very Low Very Low Very Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that TRPV4 can be sensitized by activation of PKC.


Positive_regulation (activation) of PKC Regulation (sensitized) of TRPV4
1) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.33 Pain Relevance 0.41
In this study, we have shown that: 1) TRPV1 and TRPV4 are co-expressed in a population of DRG neurons and their terminals in spinal dorsal horn; 2) TRPV4 can be sensitized by activation of PKC in DRG neurons similar to that of TRPV1; 3) Activation of TRPV4 modulates synaptic transmission at the first sensory synapse in the spinal cord, which is enhanced by activation of PKC similar to that of TRPV1; 4) TRPV4, but not TRPV1 activation modulates synaptic transmission between hippocampal neurons.
Positive_regulation (activation) of PKC in neurons Regulation (sensitized) of TRPV4 associated with dorsal root ganglion, spinal dorsal horn and spinal cord
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.62 Pain Relevance 0.59

General Comments

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