INT263229

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1, Prkcg) plasma membrane (Trpv1, Prkcg) transport (Trpv1)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
synapse 1
Trpv1 (Mus musculus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 99.54 Very High Very High Very High
dorsal root ganglion 46 96.80 Very High Very High Very High
spinal dorsal horn 19 95.68 Very High Very High Very High
Inflammation 6 84.56 Quite High
Hippocampus 5 80.40 Quite High
depression 4 77.88 Quite High
Pyramidal cell 3 68.00 Quite High
qutenza 8 65.40 Quite High
TRP channel 6 27.76 Quite Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 46 96.80 Very High Very High Very High
Hypersensitivity 2 85.56 High High
INFLAMMATION 6 84.56 Quite High
Depression 4 77.88 Quite High
Nociception 8 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have shown that: 1) TRPV1 and TRPV4 are co-expressed in a population of DRG neurons and their terminals in spinal dorsal horn; 2) TRPV4 can be sensitized by activation of PKC in DRG neurons similar to that of TRPV1; 3) Activation of TRPV4 modulates synaptic transmission at the first sensory synapse in the spinal cord, which is enhanced by activation of PKC similar to that of TRPV1; 4) TRPV4, but not TRPV1 activation modulates synaptic transmission between hippocampal neurons.
TRPV1 Positive_regulation (activation) of PKC in synapse associated with dorsal root ganglion, spinal dorsal horn and spinal cord
1) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.57 Pain Relevance 0.54

General Comments

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