INT263236

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (DAG1, Prkcg) nucleus (DAG1, Prkcg) plasma membrane (DAG1, Prkcg)
nucleoplasm (DAG1) intracellular (Prkcg) response to stress (Prkcg)
Anatomy Link Frequency
hippocampus 1
DAG1 (Homo sapiens)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 14 97.96 Very High Very High Very High
bradykinin 1 97.68 Very High Very High Very High
substance P 3 97.08 Very High Very High Very High
calcitonin gene related peptide 3 96.92 Very High Very High Very High
Neuropeptide 1 96.40 Very High Very High Very High
Spinal cord 8 90.36 High High
central sensitization 2 81.16 Quite High
nMDA receptor 3 78.52 Quite High
Glutamate 5 75.96 Quite High
adenocard 1 71.80 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 46 70.40 Quite High
Pain 3 66.84 Quite High
Cognitive Disorder 94 53.72 Quite High
Nociception 8 44.48 Quite Low
Hyperalgesia 5 40.72 Quite Low
INFLAMMATION 6 39.88 Quite Low
Disease 9 30.08 Quite Low
Diabetes Mellitus 5 27.92 Quite Low
Aging 6 19.24 Low Low
Dementia 2 13.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAG activates calcium-dependent protein kinase (PKC) in the presence of calcium (Ca2+), which is mobilized by IP3.
DAG Positive_regulation (activates) of PKC
1) Confidence 0.01 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.05 Pain Relevance 0.06
It has been shown that activation of PKC by PDBu or diacylglycerol (DAG) enhances excitatory synaptic transmission in the hippocampus [37-40].
DAG Positive_regulation (activation) of PKC in hippocampus associated with hippocampus
2) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.26 Pain Relevance 0.64

General Comments

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