INT26326

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Context Info
Confidence 0.27
First Reported 1988
Last Reported 2005
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.66
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
brain 4
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
fortral 6 97.82 Very High Very High Very High
opiate 1 95.96 Very High Very High Very High
Substantia nigra 1 89.60 High High
Intracerebroventricular 1 66.28 Quite High
imagery 3 64.16 Quite High
Enkephalin 3 63.88 Quite High
MU agonist 2 61.80 Quite High
Disease Link Frequency Relevance Heat
Dystonia 2 91.28 High High
Movement Disorders 2 90.40 High High
Urological Neuroanatomy 1 88.16 High High
Dyskinesias 1 85.92 High High
Psychosis 1 76.24 Quite High
Cancer 1 63.08 Quite High
Bordatella Infection 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in sigma receptor binding.
Spec (whether) Regulation (changes) of sigma receptor Binding (binding) of
1) Confidence 0.27 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8422906 Disease Relevance 0.16 Pain Relevance 0.14
Influence of trishomocubanes on sigma receptor binding of N-(1-benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain.
Regulation (Influence) of sigma receptor Binding (binding) of in brain
2) Confidence 0.23 Published 2005 Journal Medicinal chemistry (Sh?riqah (United Arab Emirates)) Section Title Doc Link 16789883 Disease Relevance 0.06 Pain Relevance 0.11
Unlike [125I]beta h-endorphin, the binding of the putative sigma receptor agonist, (+)-[3H]SKF 10,047, was not significantly altered by GTP or guanylyl-5'-imidodiphosphate in the absence or presence of sodium.
Neg (not) Regulation (altered) of sigma receptor Binding (binding) of associated with agonist
3) Confidence 0.16 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2967350 Disease Relevance 0 Pain Relevance 0.29
Subchronic administration of N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) alters sigma 1 receptor binding.
Regulation (alters) of sigma 1 receptor Binding (binding) of associated with fortral
4) Confidence 0.14 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9137911 Disease Relevance 0.44 Pain Relevance 0.18
In order to elucidate the mechanisms involved in sigma receptor ligand binding, equilibrium binding analysis and kinetics of association and dissociation of the relatively selective sigma receptor ligand (+)-[3H]3-PPP were determined in rat brain membranes in the absence and presence of 5'-guanylylimidodiphosphate [Gpp(NH)p].
Regulation (involved) of sigma receptor Binding (binding) of in brain
5) Confidence 0.12 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2554109 Disease Relevance 0 Pain Relevance 0.17

General Comments

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