INT26333

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.17
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
spike 4
reticulum 2
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 99 99.50 Very High Very High Very High
Inflammation 25 86.00 High High
antagonist 78 84.16 Quite High
local anesthetic 1 62.32 Quite High
cytokine 78 52.80 Quite High
Potency 77 41.56 Quite Low
Glutamate 2 32.56 Quite Low
chemokine 2 31.92 Quite Low
bradykinin 4 17.36 Low Low
Inflammatory response 3 9.12 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 86.00 High High
Disease 5 13.28 Low Low
Hypersensitivity 24 5.00 Very Low Very Low Very Low
Edema 15 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Ocular Hypertension 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Conjunctivitis 6 5.00 Very Low Very Low Very Low
Pruritus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].
Positive_regulation (causing) of Localization (release) of IP3 receptor
1) Confidence 0.43 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.09 Pain Relevance 0.08
In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].
Positive_regulation (activate) of Localization (release) of IP3 receptor
2) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.09 Pain Relevance 0.09
In this model, an agonist-induced increase in IP3 stimulates the release of calcium from an IP3-sensitive intracellular calcium storage site into the cytoplasm.
Positive_regulation (stimulates) of Localization (release) of IP3 associated with agonist
3) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.08
However, after such a store is full, the subsequent accumulation of calcium in the cytoplasm can then activate a rapid calcium-induced calcium release from the same IP3-insensitive store, which produces the onset of the calcium spike.
Positive_regulation (induced) of Localization (release) of IP3 in spike
4) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.11
However, after such a store is full, the subsequent accumulation of calcium in the cytoplasm can then activate a rapid calcium-induced calcium release from the same IP3-insensitive store, which produces the onset of the calcium spike.
Positive_regulation (activate) of Localization (release) of IP3 in spike
5) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.11
activation leading to increases in IP3 generation and mobilization of [Ca2+]i.
Positive_regulation (increases) of Localization (generation) of IP3
6) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
Further evidence that different channels are involved is presented by way of demonstration of the lack of Ca2+-induced Ca2+ release from these brain microsomes and the lack of effect on sarcoplasmic reticulum caffeine-induced Ca2+ release of certain inhibitors of IP3-induced Ca2+ release used here.
Positive_regulation (induced) of Localization (release) of IP3 in reticulum
7) Confidence 0.02 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2554117 Disease Relevance 0 Pain Relevance 0.09

General Comments

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