INT26336

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Context Info
Confidence 0.13
First Reported 1986
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
brain 2
reticulum 2
SK-N-SH 2
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 100.00 Very High Very High Very High
local anesthetic 1 84.20 Quite High
bradykinin 2 80.16 Quite High
Immobilon 2 75.60 Quite High
Delta opioid receptors 2 75.00 Quite High
antagonist 1 73.88 Quite High
Enkephalin 3 72.96 Quite High
Glutamate 42 67.68 Quite High
long-term potentiation 1 62.08 Quite High
Glutamate receptor 12 37.92 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 3 98.24 Very High Very High Very High
Glioma 1 97.44 Very High Very High Very High
Toxicity 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of opioids on phosphatidylinositol (PI) turnover to release inositol triphosphate (IP3) as second messenger was examined in mouse neuroblastoma X rat glioma hybrid cells NG108-15 (delta-receptors) and human neuroblastoma cells, SK-N-SH (predominantly mu-receptors).
Spec (examined) Regulation (effect) of Localization (release) of IP3 in SK-N-SH associated with neuroblastoma, opioid and glioma
1) Confidence 0.13 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3024076 Disease Relevance 0.37 Pain Relevance 0.42
In addition, caffeine also acts on the other primary endoplasmic reticulum calcium release channel, the inositol triphosphate receptor (IP3R), over the same concentration range.
Regulation (acts) of Localization (release) of IP3R in reticulum
2) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0.06
In contrast, a number of blockers of other Ca2+ channels (nifedipine, verapamil, dantrolene, dithiothreitol, and ruthenium red) have relatively little or no effect on IP3-induced Ca2+ release from brain microsomes.
Neg (no) Regulation (effect) of Localization (release) of IP3 in brain
3) Confidence 0.01 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2554117 Disease Relevance 0 Pain Relevance 0.12

General Comments

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