INT26337

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Context Info
Confidence 0.30
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.11
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton organization (Hmmr) cell-cell signaling (Hmmr) cytoplasm (Hmmr)
Anatomy Link Frequency
neuronal 1
nucleus 1
ventral 1
Hmmr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 100.00 Very High Very High Very High
Paracetamol 14 99.96 Very High Very High Very High
Dopamine 146 99.20 Very High Very High Very High
opioid receptor 5 98.98 Very High Very High Very High
antagonist 9 98.08 Very High Very High Very High
narcan 1 97.60 Very High Very High Very High
agonist 14 96.32 Very High Very High Very High
Nicotine 86 95.72 Very High Very High Very High
Ventral tegmentum 138 95.12 Very High Very High Very High
diclofenac 4 92.80 High High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 1 99.84 Very High Very High Very High
Hepatotoxicity 3 99.82 Very High Very High Very High
Pathologic Constriction 1 98.18 Very High Very High Very High
Poisoning 1 86.72 High High
Generalized Anxiety Disorder 2 85.76 High High
Keratosis 1 77.32 Quite High
Carcinoma 1 76.44 Quite High
Pain 1 75.56 Quite High
Osteoarthritis 1 75.36 Quite High
Injury 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the transmission of visceral sensory information within the nucleus tractus solitarius may be controlled by opposing alpha 1- and alpha 2-receptor-mediated neural systems.
Negative_regulation (opposing) of alpha 2-receptor-mediated in nucleus
1) Confidence 0.30 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2554181 Disease Relevance 0 Pain Relevance 0.13
In rabbits, stenosis following balloon angioplasty is prevented by a subcutaneous dose of HA, probably through blockade of cell-surface HA receptors (ICAM-1, CD44 & RHAMM).
Negative_regulation (blockade) of RHAMM associated with pathologic constriction
2) Confidence 0.07 Published 1995 Journal Int J Tissue React Section Abstract Doc Link 8867645 Disease Relevance 0.40 Pain Relevance 0.32
Systemically administered MK-801 was found to protect against neurodegeneration caused by NMDA (200 nmol) and the naturally occurring NMDA receptor agonist quinolinate (120-600 nmol) but not against that induced by kainate (5 nmol) or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA; 50 nmol), indicating a selectivity for NMDA receptor-mediated neuronal loss.
Negative_regulation (loss) of receptor-mediated in neuronal associated with nmda receptor and agonist
3) Confidence 0.06 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2904493 Disease Relevance 0.25 Pain Relevance 0.40
The existence of a tonic GABAB receptor-mediated inhibition of somatodendritic DA release has been suggested by the evidence that, in vivo, the administration of CGP55845A into the ventral tegmental area produces a dose-dependent increase in VTA dopamine levels [49].
Negative_regulation (inhibition) of receptor-mediated in ventral associated with ventral tegmentum and dopamine
4) Confidence 0.04 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.75
The GABAB receptor-mediated inhibition of the activity of the mesocorticolimbic neurones might explain the effectiveness of baclofen to suppress nicotine self-administration when microinjected into the VTA [34].
Negative_regulation (inhibition) of receptor-mediated associated with ventral tegmentum and nicotine
5) Confidence 0.04 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.04
In conclusion, the data suggest that arjunolic acid affords protection against acetaminophen-induced hepatotoxicity through inhibition of P450-mediated APAP bioactivation and inhibition of JNK-mediated activation of mitochondrial permeabilization.
Negative_regulation (inhibition) of P450-mediated associated with paracetamol and hepatotoxicity
6) Confidence 0.02 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19969075 Disease Relevance 0.45 Pain Relevance 0.91
A cluster of Ser/Thr residues at the C-terminus of mu-opioid receptor is required for G protein-coupled receptor kinase 2-mediated desensitization.
Negative_regulation (desensitization) of 2-mediated associated with narcan and opioid receptor
7) Confidence 0.00 Published 2000 Journal Neuropharmacology Section Title Doc Link 10698001 Disease Relevance 0 Pain Relevance 0.46

General Comments

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