INT263387

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.86
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abl1) nucleus (Abl1) kinase activity (Abl1)
cytoplasm (Abl1)
Anatomy Link Frequency
neurons 2
pyramidal neurons 1
Abl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 15 100.00 Very High Very High Very High
nMDA receptor 186 97.76 Very High Very High Very High
Pyramidal cell 12 96.56 Very High Very High Very High
Hippocampus 24 81.44 Quite High
Nucleus accumbens 37 78.96 Quite High
depression 48 76.64 Quite High
long-term potentiation 30 63.60 Quite High
Potency 5 61.52 Quite High
Dopamine 8 55.64 Quite High
antagonist 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 116 97.92 Very High Very High Very High
Fibromyalgia 6 87.00 High High
Depression 48 76.64 Quite High
Leukemia 13 57.12 Quite High
Targeted Disruption 12 51.12 Quite High
Genetic Translocation 6 48.16 Quite Low
Hypercalcemia 14 38.36 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Multiple Myeloma 6 5.00 Very Low Very Low Very Low
Osteoporosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
receptors decreases the association of Abl with these interacting partners as well as causing an increase in the tyrosine phosphorylation of Abl kinase.


Abl Binding (association) of
1) Confidence 0.42 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
receptors and Abl kinase physically associate in hippocampal neurons.
Abl kinase Binding (associate) of in neurons
2) Confidence 0.42 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.19 Pain Relevance 0.08
ABL also seems to be critically involved in this setting, particularly for the acquisition of cue–outcome associations in the present task (Hatfield et al., 1996).
ABL Binding (associations) of associated with amygdala
3) Confidence 0.36 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2981418 Disease Relevance 0 Pain Relevance 0.31
Upon treatment of acutely isolated hippocampal slices with PDGF-BB, the association of Abl with each of these proteins is decreased and this coincides with an increase in tyrosine phosphorylation of Abl kinase.
Abl Binding (association) of
4) Confidence 0.32 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.05 Pain Relevance 0.09
These data show that treatment of CA1 hippocampal slices results in an increase in Abl tyrosine kinase phosphorylation and a change in the association of Abl kinase with the PDGF receptor.
Abl kinase Binding (association) of
5) Confidence 0.32 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
Therefore, in addition to being crucial for neuronal development, Abl kinase regulates NMDA function in mature neurons and links PDGF?
Abl kinase Binding (links) of in neurons
6) Confidence 0.32 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.21
receptors act via an interaction with Abl kinase and Rho kinase to regulated cytoskeletal regulation of NMDA receptor channels in CA1 pyramidal neurons.



Abl kinase Binding (interaction) of in pyramidal neurons associated with pyramidal cell and nmda receptor
7) Confidence 0.31 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.18
Gene expression determined by Q-PCR was normalized to human GUS and ABL, and the relative expression is shown as a percentage compared to control cultures treated with M-CSF and RANKL.
ABL Binding (normalized) of
8) Confidence 0.06 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox