INT263398

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 1.44
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abl1) nucleus (Abl1) kinase activity (Abl1)
cytoplasm (Abl1)
Anatomy Link Frequency
neurons 7
Abl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 75 99.08 Very High Very High Very High
nMDA receptor 465 98.28 Very High Very High Very High
Hippocampus 60 96.88 Very High Very High Very High
depression 120 94.48 High High
tetrodotoxin 15 63.96 Quite High
Central nervous system 15 61.24 Quite High
Dopamine 15 35.04 Quite Low
Pyramidal cell 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 120 94.48 High High
Genetic Translocation 15 88.00 High High
Targeted Disruption 30 82.96 Quite High
Leukemia 30 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
receptors can activate the cytoplasmic pool of Abl kinase.
Positive_regulation (activate) of Abl kinase
1) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.35 Pain Relevance 0.12
Despite the identification of Abl as an important regulator of several neuronal processes, it remains unclear how Abl is activated in neurons.
Positive_regulation (activated) of Abl in neurons
2) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.14 Pain Relevance 0.09
receptor activation could activate Abl kinase in hippocampal neurons, we incubated acutely dissected CA1 hippocampal slices with the PDGF?
Positive_regulation (activate) of Abl kinase in neurons
3) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.28 Pain Relevance 0.09
In cortical neurons, Abl and Arg are required for normal dendritic branching and are activated downstream of integrin receptors [17,20].
Positive_regulation (activated) of Abl in neurons
4) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.33
receptors to activate Abl kinase in hippocampal neurons, we monitored the phosphorylation state of Abl kinase after incubation of hippocampal slices with PDGF-BB.
Positive_regulation (activate) of Abl kinase in neurons
5) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.05 Pain Relevance 0.06
Several lines of evidence link cell surface receptors to the activation of Abl kinase.
Positive_regulation (activation) of Abl kinase
6) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.07 Pain Relevance 0.07
There was a trend towards an increase in immunoreactivity for Abl kinase in the triton-insoluble fraction (Figure 3A, B), suggesting that Abl kinase is moving from the cytosolic and light membrane fraction to the triton-insoluble fraction.
Positive_regulation (increase) of Abl kinase
7) Confidence 0.43 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.04
In several systems, Abl kinases are also required for Rho-family GTPase coupling to the actin cytoskeleton and can reciprocally signal to ROCK [25].
Positive_regulation (required) of Abl
8) Confidence 0.43 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.14 Pain Relevance 0.09
The identification of Abl as a downstream target in hippocampal neurons coupled with the requirement of Src to fully activate Abl after PDGF receptor activation may help reconcile the apparent contradiction in the requirement of Src for an inhibition of NMDA receptor currents by PDGF receptor activation and the direct potentiation of NMDA receptors by Src [14].
Positive_regulation (activate) of Abl in neurons associated with nmda receptor
9) Confidence 0.43 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.21
In contrast, the inclusion of heat-inactivated Abl kinase in the patch pipette did not depress NMDA currents such that peak currents were maintained for the 25 minutes of recording (104 ± 8%, Figure 1A, C).
Positive_regulation (inactivated) of Abl kinase
10) Confidence 0.43 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.41 Pain Relevance 0.13
receptors activate Abl kinase in hippocampal neurons and that Abl links PDGF?
Positive_regulation (activate) of Abl kinase in neurons
11) Confidence 0.40 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.12
We show that the inhibition of NMDA receptor currents by Abl kinase is blocked by the inclusion of the Rho kinase inhibitor, Y-27632, and that activation of Abl correlates with an increase in ROCK tyrosine phosphorylation.


Positive_regulation (activation) of Abl associated with nmda receptor
12) Confidence 0.40 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.09
receptor activation activates Abl in HEK293 cells in a Src- and PLC?
Positive_regulation (activates) of Abl
13) Confidence 0.40 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
and Src, suggesting that Abl is activated in hippocampal neurons in a manner similar as previously reported in non-neuronal cells.
Positive_regulation (activated) of Abl in neurons
14) Confidence 0.40 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.12
Abl or heat-inactivated Abl (0.5 ?
Positive_regulation (inactivated) of Abl
15) Confidence 0.38 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.11

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