INT263404

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.66
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abl1) nucleus (Abl1) kinase activity (Abl1)
cytoplasm (Abl1)
Anatomy Link Frequency
neurons 5
Abl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 186 93.44 High High
Central nervous system 6 91.24 High High
depression 48 79.76 Quite High
long-term potentiation 30 46.48 Quite Low
Dopamine 6 38.40 Quite Low
Hippocampus 24 5.00 Very Low Very Low Very Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 96.16 Very High Very High Very High
Depression 48 79.76 Quite High
Genetic Translocation 6 22.56 Low Low
Leukemia 12 14.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most detailed studies on the regulation of Abl involve the activation of Abl by PDGF?
Regulation (regulation) of Abl
1) Confidence 0.53 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.06 Pain Relevance 0.07
Despite the identification of Abl as an important regulator of several neuronal processes, it remains unclear how Abl is activated in neurons.
Regulation (regulator) of Abl in neurons
2) Confidence 0.39 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.14 Pain Relevance 0.11
In hippocampal neurons, Abl appears to be regulated by similar mechanisms.
Spec (appears) Regulation (regulated) of Abl in neurons
3) Confidence 0.23 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.06 Pain Relevance 0.06
Mechanisms of Abl regulation by cell surface receptors and intracellular signaling pathways in neurons remain unclear, and the role of Abl in post-synaptic neuronal signaling, specifically in NMDA receptor regulation, is unknown.
Regulation (regulation) of Abl in neurons associated with nmda receptor
4) Confidence 0.23 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.10 Pain Relevance 0.09
receptors and Abl as well as the evidence of Abl kinase regulation of neuronal signaling and development, we examined the possibility that in CA1 neurons Abl kinase is activated downstream of PDGF?
Regulation (regulation) of Abl in neurons
5) Confidence 0.23 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.15 Pain Relevance 0.10
receptors and Abl as well as the evidence of Abl kinase regulation of neuronal signaling and development, we examined the possibility that in CA1 neurons Abl kinase is activated downstream of PDGF?
Regulation (regulation) of Abl kinase in neurons
6) Confidence 0.23 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.15 Pain Relevance 0.08

General Comments

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