INT263405

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.05
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abl1) nucleus (Abl1) kinase activity (Abl1)
cytoplasm (Abl1)
Anatomy Link Frequency
neurons 1
Abl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 155 74.80 Quite High
long-term potentiation 25 71.44 Quite High
Hippocampus 20 56.16 Quite High
depression 40 51.36 Quite High
Central nervous system 5 41.88 Quite Low
Pyramidal cell 10 5.00 Very Low Very Low Very Low
tetrodotoxin 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 40 51.36 Quite High
Targeted Disruption 10 46.80 Quite Low
Leukemia 10 31.84 Quite Low
Genetic Translocation 5 22.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that treatment of CA1 hippocampal slices results in an increase in Abl tyrosine kinase phosphorylation and a change in the association of Abl kinase with the PDGF receptor.
Phosphorylation (phosphorylation) of Abl
1) Confidence 0.71 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
Upon treatment of acutely isolated hippocampal slices with PDGF-BB, the association of Abl with each of these proteins is decreased and this coincides with an increase in tyrosine phosphorylation of Abl kinase.
Phosphorylation (phosphorylation) of Abl kinase
2) Confidence 0.71 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.10
Treatment with PDGF-BB for 10 minutes enhanced the tyrosine phosphorylation of Abl kinase (Figure 2B, 4.2 ± 0.8 fold vs. control, n = 7, p < 0.05 unpaired Student's t-test).
Phosphorylation (phosphorylation) of Abl kinase
3) Confidence 0.71 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.03
receptors decreases the association of Abl with these interacting partners as well as causing an increase in the tyrosine phosphorylation of Abl kinase.


Phosphorylation (phosphorylation) of Abl kinase
4) Confidence 0.71 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
receptors to activate Abl kinase in hippocampal neurons, we monitored the phosphorylation state of Abl kinase after incubation of hippocampal slices with PDGF-BB.
Phosphorylation (phosphorylation) of Abl kinase in neurons
5) Confidence 0.71 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

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