INT263408

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.28
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abl1) nucleus (Abl1) kinase activity (Abl1)
cytoplasm (Abl1)
Abl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 93 95.80 Very High Very High Very High
long-term potentiation 15 74.16 Quite High
Central nervous system 3 73.24 Quite High
Hippocampus 12 58.28 Quite High
antagonist 5 50.00 Quite Low
depression 24 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 78.16 Quite High
Respiratory Syncytial Virus 116 72.72 Quite High
Fibromyalgia 6 46.92 Quite Low
Depression 24 5.00 Very Low Very Low Very Low
Hypercalcemia 14 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Leukemia 7 5.00 Very Low Very Low Very Low
Multiple Myeloma 6 5.00 Very Low Very Low Very Low
Osteoporosis 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDGF receptor activation decreases the cytoplasmic pool of Abl kinase
Gene_expression (pool) of Abl kinase
1) Confidence 0.58 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
These observations show that ROCK is required for Abl-mediated changes in the actin cytoskeleton that leads to inhibition of NMDA currents and that Abl-mediated inhibition of NMDA receptor currents requires RhoGTPase and ROCK signaling (Figure 5).
Gene_expression (changes) of Abl-mediated associated with nmda receptor
2) Confidence 0.58 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.25
Although Abl and PDGF?
Gene_expression (Although) of Abl
3) Confidence 0.58 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.08 Pain Relevance 0.08
The quantity of the target gene mRNA was then obtained by division of each value by the mean relative gene expression of human GUS (36-3026) and ABL (06-1250) used as endogenous controls [10].


Gene_expression (expression) of ABL
4) Confidence 0.11 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.21 Pain Relevance 0

General Comments

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