INT263454

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) DNA binding (IRF6)
cytoplasm (IRF6) cytosol (IRF6) signal transduction (TNF)
Anatomy Link Frequency
leukocytes 2
IRF6 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 35 100.00 Very High Very High Very High
Inflammatory response 57 95.40 Very High Very High Very High
Inflammation 87 83.28 Quite High
cytokine 13 82.24 Quite High
corticosteroid 56 79.48 Quite High
cINOD 2 46.08 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 154 95.04 Very High Very High Very High
Stress 1 35.20 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Systemic Inflammatory Response Syndrome 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Critical Illness 1 5.00 Very Low Very Low Very Low
Hepatotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These in silico results lie in agreement with studies [31] that suggest a dose-dependent decrease in LPS-induced TNF in peripheral human blood leukocytes that are exposed to hydrocortisone infusion.
Negative_regulation (decrease) of LPS Positive_regulation (induced) of TNF in leukocytes associated with inflammatory stimuli
1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.49 Pain Relevance 0.59

General Comments

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