INT263502

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.12
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Abph) cellular_component (Abph) biological_process (Abph)
Anatomy Link Frequency
neurons 2
neuronal 1
entopeduncular nucleus 1
Abph (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 81 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
Substantia nigra 18 98.14 Very High Very High Very High
substance P 21 97.48 Very High Very High Very High
Dynorphin 15 97.16 Very High Very High Very High
cerebral cortex 9 89.64 High High
Pyramidal cell 3 88.72 High High
midbrain 3 87.44 High High
Thalamus 6 85.00 Quite High
GABAergic 24 80.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 114 65.44 Quite High
Cognitive Disorder 6 57.72 Quite High
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Handedness 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This last group was divided into Type IIa (projecting to the LGP, MGP, and SNr) and Type IIb (projecting to the LGP and SNr).
Gene_expression (projecting) of LGP
1) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.05
MSNs expressing dopamine D1-receptors (D1Rs), dynorphin and substance P, project to the substantia nigra pars reticulata (SNr) and entopeduncular nucleus (direct striatonigral pathway), while MSNs expressing dopamine D2-receptors (D2Rs) and enkephalin, project to the lateral part of the globus pallidus (LGP) (indirect striatopallidal pathway) [5]–[7].
Gene_expression (expressing) of LGP in entopeduncular nucleus associated with dopamine, dynorphin, substantia nigra, enkephalin and substance p
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.12 Pain Relevance 0.62
While the injection of a retrograde neuronal tracer in the SNr of drd1a- and drd2-EGFP mice showed that virtually all MSNs projecting to the SNr expressed the D1R and very few D2R (<1%) (Gertler et al., 2008; Matamales et al., 2009), sparse EGFP-positive fibers were detected in the LGP of drd1a-Cre and drd1a-EGFP mice (Gong et al., 2007; Matamales et al., 2009).
Gene_expression (detected) of LGP in neuronal
3) Confidence 0.15 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.16
This last group was divided into Type IIa (projecting to the LGP, MGP, and SNr) and Type IIb (projecting to the LGP and SNr).
Gene_expression (projecting) of LGP
4) Confidence 0.15 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.05
Although it is clear that most striatal neurons are MSNs which project to the SNr or the LGP and express distinct proteins, the degree of segregation of these two populations has been intensely debated.
Gene_expression (project) of LGP in neurons
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0.22
On the other hand, observations in our and other laboratories support the existence of a small fraction of D1R-neuron projections to the pallidum, since weak but noticeable staining is present in the LGP of drd1a-Cre, chrm4-EGFP and drd1a-EGFP mice [12], [13], [19].
Gene_expression (present) of LGP in neuron
6) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0

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