INT263572

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.15
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
retina 2
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 25 77.16 Quite High
nMDA receptor antagonist 10 57.36 Quite High
anesthesia 15 5.00 Very Low Very Low Very Low
isoflurane 15 5.00 Very Low Very Low Very Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
excitatory amino acid 10 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 314 99.64 Very High Very High Very High
Injury 20 98.28 Very High Very High Very High
Ganglion Cysts 120 94.08 High High
Apoptosis 60 89.44 High High
Death 160 88.24 High High
Cv Unclassified Under Development 20 77.16 Quite High
Ocular Hypertension 105 70.80 Quite High
Drug Induced Neurotoxicity 16 61.08 Quite High
Malaria 45 59.12 Quite High
Infection 62 58.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further clarify the participation of ER stress, we examined the changes in BiP and CHOP in the retina after NMDA-induced injury.
Spec (examined) Regulation (changes) of BiP in retina associated with stress and injury
1) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.16 Pain Relevance 0.07
To clarify whether ER stress-related proteins other than XBP-1 are induced in the mouse retina by NMDA stimulation, we examined the changes in BiP, a biomarker of ER stress, in the retina after intravitreal injection of NMDA.
Spec (examined) Regulation (changes) of BiP in retina associated with stress
2) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.45 Pain Relevance 0
(active form) may remain to translate BiP and CHOP mRNAs to proteins.
Regulation (translate) of BiP
3) Confidence 0.30 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.95 Pain Relevance 0
Next, we investigated the distribution and time-course of changes in GRP78/BiP and CHOP, a proapoptosis protein, after NMDA injection.
Spec (investigated) Regulation (changes) of GRP78/BiP
4) Confidence 0.18 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.49 Pain Relevance 0
Time-course data for the changes in the protein levels of glucose-regulated protein (GRP)78/BiP, the phosphorylated form of eukaryotic initiation factor 2?
Regulation (changes) of BiP
5) Confidence 0.18 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.31 Pain Relevance 0
Nichols and Kirby [42] also noted that pyrazole produced a greater increase in GRP78 protein in G6PD-deficient mice than in wild type mice, and that menadione did not alter GRP78 levels either in wild type or in G6PD-deficient animals.
Neg (not) Regulation (alter) of GRP78
6) Confidence 0.16 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.79 Pain Relevance 0

General Comments

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