INT263635

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.35
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (NAGK)
NAGK (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 25 93.40 High High
Bile 20 74.52 Quite High
abdominal pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pseudomonas Infection 5 100.00 Very High Very High Very High
Gastroenteritis 20 53.92 Quite High
Diarrhoea 20 51.44 Quite High
Adhesions 10 25.00 Low Low
Sprains And Strains 20 5.00 Very Low Very Low Very Low
Bordatella Infection 10 5.00 Very Low Very Low Very Low
Alcoholic Liver Cirrhosis 5 5.00 Very Low Very Low Very Low
Ulcers 5 5.00 Very Low Very Low Very Low
Gonorrhea 5 5.00 Very Low Very Low Very Low
Aids-related Complex 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the kinase activities of NAGK-20 and NAGK-37 were examined with and without 0.25, 0.5, 0.75, 1, 2.5, 5, 10, and 20 mM of L-arginine and incubated at 37°C for 30 min.
Negative_regulation (Inhibition) of NAGK-20
1) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2652115 Disease Relevance 0 Pain Relevance 0.12
NAGK-20 also had a lower optimal temperature for enzymatic activities and was inhibited by arginine probably as negative-feedback control.
Negative_regulation (inhibited) of NAGK-20
2) Confidence 0.30 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2652115 Disease Relevance 0.16 Pain Relevance 0.08
Inhibition of the kinase activities of NAGK-20 and NAGK-37 were examined with and without 0.25, 0.5, 0.75, 1, 2.5, 5, 10, and 20 mM of L-arginine and incubated at 37°C for 30 min.
Negative_regulation (Inhibition) of NAGK
3) Confidence 0.25 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2652115 Disease Relevance 0 Pain Relevance 0.12
Similar to NAGK-20 of L. hongkongensis, NAGK of Pseudomonas aeruginosa and Thermotoga maritima, which employ the cyclic pathway, can be inhibited by arginine as the rate-limiting enzyme for negative feedback control [34]–[37].
Negative_regulation (inhibited) of NAGK associated with pseudomonas infection
4) Confidence 0.22 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2652115 Disease Relevance 0.10 Pain Relevance 0
On the other hand, similar to NAGK-37 of L. hongkongensis, NAGK of E. coli, which employs the linear pathway, is not inhibited by arginine [35],[36].
Negative_regulation (inhibited) of NAGK
5) Confidence 0.22 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2652115 Disease Relevance 0.09 Pain Relevance 0

General Comments

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