INT26364

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Context Info
Confidence 0.30
First Reported 1988
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.99
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CS) small molecule metabolic process (CS) carbohydrate metabolic process (CS)
Anatomy Link Frequency
lung 2
muscle 1
proximal 1
respiratory 1
CS (Homo sapiens)
Pain Link Frequency Relevance Heat
Endep 10 99.78 Very High Very High Very High
Restless leg syndrome 3 97.96 Very High Very High Very High
tetrodotoxin 9 97.04 Very High Very High Very High
Nicotine 36 84.48 Quite High
c fibre 2 81.72 Quite High
nociceptor 5 78.12 Quite High
cva 1 75.00 Quite High
Glutamate 2 70.96 Quite High
Inflammatory response 4 55.84 Quite High
Lasting pain 1 53.72 Quite High
Disease Link Frequency Relevance Heat
Fatigue 20 99.64 Very High Very High Very High
Cancer 160 99.40 Very High Very High Very High
Malignant Neoplastic Disease 80 98.84 Very High Very High Very High
Stress 270 98.76 Very High Very High Very High
Lung Cancer 188 98.68 Very High Very High Very High
Mitochondrial Disorders 26 98.56 Very High Very High Very High
Nicotine Addiction 120 98.32 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.96 Very High Very High Very High
Hypoxia 48 95.56 Very High Very High Very High
Atrial Flutter 17 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, amitriptyline treatment induced a significant decrease of cytochrome c, DeltaPsi(m), and citrate synthase activity; revealing mitochondrial damage.
Positive_regulation (induced) of citrate synthase associated with endep
1) Confidence 0.30 Published 2008 Journal Toxicology Section Abstract Doc Link 17980474 Disease Relevance 0.19 Pain Relevance 0.43
Conversely, flutter localized to the superior right atrium may activate the distal CS earlier than the proximal CS, via Bachmann’s bundle.
Positive_regulation (activate) of CS in proximal
2) Confidence 0.28 Published 2006 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1501100 Disease Relevance 0.42 Pain Relevance 0
It is also possible that the UPR is induced in CS-exposed lung cells prior to malignancy but also subsequent to the development of a cancer that has regions of hypoxia.
Positive_regulation (induced) of CS in lung associated with malignant neoplastic disease, hypoxia and cancer
3) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.69 Pain Relevance 0
Examination of the most significant clusters (p-value < 0.01) for the 4 h upregulated CS signature revealed several processes characteristic of exposure to xenobiotics such as response to stress, response to chemical stimulus, and response to abiotic stimulus.
Positive_regulation (upregulated) of CS associated with stress
4) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.23 Pain Relevance 0
Each of these CS-responsive genes is frequently upregulated in a range of cancers including lung carcinomas [120-123].
Positive_regulation (upregulated) of CS in lung associated with lung cancer and cancer
5) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.63 Pain Relevance 0.03
CS was generated under Federal Trade Commission (FTC)[40] smoking conditions (35 ± 0.3 cc puff, one puff every 60 seconds, 2-second puff duration with none of the ventilation holes blocked) using a KC 5 Port Smoker (KC Automation, Richmond, VA), from 2R4F reference research cigarette (designed to represent the average 'lights' cigarette marketed in the U.S. with FTC values of 9.7 mg 'tar' and 0.85 mg nicotine; University of Kentucky, Louisville, KY) using FTC machine smoking conditions, or two leading commercially available U.S. cigarette brands representative of either the 'lights' (FTC values of 11 mg 'tar' and 0.8 mg nicotine) or 'full-flavor' (FTC values of 15 mg 'tar' and 1.1 mg nicotine) styles of cigarettes.
Positive_regulation (generated) of CS associated with nicotine addiction and nicotine
6) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.18 Pain Relevance 0.12
The activities of CS, ACDH and Cyt-ox were increased and the activity of Cytox was positively correlated to the maximal walking distance (MWD) in the patients. 2.
Positive_regulation (increased) of CS
7) Confidence 0.14 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2555105 Disease Relevance 0.26 Pain Relevance 0.22
Swimming but not climbing increased the activity of CS and the fatigue resistance of the muscle.
Positive_regulation (increased) of CS in muscle associated with fatigue
8) Confidence 0.12 Published 1988 Journal Exp. Neurol. Section Abstract Doc Link 2970977 Disease Relevance 0.51 Pain Relevance 0.61
Other studies have found similar results with studies reporting large increases in citrate synthase maximal activity after 2 weeks [32] and 6 weeks of HIIE [37].
Positive_regulation (increases) of citrate synthase
9) Confidence 0.04 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.07 Pain Relevance 0
There was an elevation of citrate synthase activity in the muscle tissue (+47%) (Figure 3B) consistent with a mitochondrial proliferation often observed in respiratory chain deficient tissues.
Positive_regulation (elevation) of citrate synthase in respiratory
10) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2683749 Disease Relevance 0 Pain Relevance 0.04
Increased citrate synthase activity is frequently observed in mitochondrial disorders and is thought to reflect mitochondrial proliferation in response to energy deficit in the diseased tissue [12],[15].
Positive_regulation (Increased) of citrate synthase associated with mitochondrial disorders
11) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2683749 Disease Relevance 0.10 Pain Relevance 0
The mCS (but not the eCS) sometimes evoked a paradoxical increase in response to the test-heat stimulus.
Positive_regulation (increase) of eCS
12) Confidence 0.01 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805316 Disease Relevance 0.71 Pain Relevance 0.44

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