INT263672

Context Info Confidence 0.50 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 0.12 Pain Relevance 0.15

plasma membrane (Neto1)

Anatomy Link Frequency tail 2 synapses 2 Neto1 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 60 78.24 Glutamate receptor 10 72.68 antagonist 5 38.60 long-term potentiation 130 5.00 nMDA receptor 45 5.00 Pyramidal cell 20 5.00 Central nervous system 15 5.00 Neurotransmitter 15 5.00 Eae 10 5.00 Glutamate 10 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 30 64.08 Cognitive Disorder 40 5.00 Convulsion 10 5.00 Sprains And Strains 5 5.00 Helminth Infection 5 5.00 Influenza Virus Infection 5 5.00 Contagious Ecthyma 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Removal of the cytoplasmic tail and transmembrane domain of Neto1 did not abolish the Neto1:NMDAR interaction (Figure 4B, lanes 2 and 3), suggesting that it was mediated by the ectodomain of Neto1.

Positive_regulation (mediated) of Gene_expression (ectodomain) of Neto1 in tail

1) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

These findings indicate that tbLTP in Schaffer collateral-CA1 synapses of adult Neto1-null mice is mediated primarily by NR2B-containing NMDARs.

Positive_regulation (mediated) of Gene_expression (synapses) of Neto1-null in synapses

2) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07

Generation of Neto1-Null Mice

Positive_regulation (Generation) of Gene_expression (Generation) of Neto1-Null

3) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.12 Pain Relevance 0

Moreover, Neto1 or Neto1-?

Positive_regulation (Moreover) of Gene_expression (Moreover) of Neto1

4) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04

Moreover, Neto1 or Neto1-?

Positive_regulation (Moreover) of Gene_expression (Moreover) of Neto1

5) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.04

General Comments

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