INT263675

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.45
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Neto1)
Anatomy Link Frequency
brain 3
tail 1
spines 1
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 84 97.12 Very High Very High Very High
cerebral cortex 7 95.12 Very High Very High Very High
Central nervous system 21 92.24 High High
long-term potentiation 182 62.76 Quite High
Glutamate receptor 14 44.08 Quite Low
Neurotransmitter 21 18.84 Low Low
nMDA receptor 63 5.00 Very Low Very Low Very Low
Pyramidal cell 28 5.00 Very Low Very Low Very Low
Eae 14 5.00 Very Low Very Low Very Low
Glutamate 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 56 96.60 Very High Very High Very High
Congenital Anomalies 42 94.80 High High
Contagious Ecthyma 7 81.92 Quite High
Convulsion 14 24.00 Low Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Helminth Infection 7 5.00 Very Low Very Low Very Low
Influenza Virus Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, using crude synaptosomal fractions, we determined that anti-PSD-95 antibodies co-immunoprecipitated Neto1 from wild-type (Neto1+/+) mouse brain (Figure 2E).
Localization (immunoprecipitated) of Neto1 in brain
1) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Localization (absence) of Neto1 in brain
2) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.18 Pain Relevance 0.05
Negative control antibodies did not immunoprecipitate either Neto1 or PSD-95 (Figures 2E and 3A).
Neg (not) Localization (immunoprecipitate) of Neto1
3) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.06
We also found that Neto1 co-localized with actin (Figure 2D), which is highly enriched in dendritic spines in the hippocampus [20].
Localization (localized) of Neto1 in spines associated with hippocampus
4) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.19
Removal of the cytoplasmic tail and transmembrane domain of Neto1 did not abolish the Neto1:NMDAR interaction (Figure 4B, lanes 2 and 3), suggesting that it was mediated by the ectodomain of Neto1.
Localization (domain) of Neto1 in tail
5) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
To identify the subcellular compartments in which Neto1 is localized, we performed subcellular fractionation and immunoblotting experiments of whole mouse brain lysates.
Localization (localized) of Neto1 in brain
6) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.20
Neto1 cloning and gene targeting.
Localization (targeting) of Neto1
7) Confidence 0.65 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.27 Pain Relevance 0

General Comments

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