INT263689

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 5.15
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
cleavage 2
SH-SY5Y 1
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 92.72 High High
Neurotransmitter 4 66.56 Quite High
Glutamate 5 65.68 Quite High
Hippocampus 12 63.36 Quite High
anesthesia 6 29.60 Quite Low
Inflammation 21 12.88 Low Low
Inflammatory mediators 3 7.76 Low Low
imagery 54 5.00 Very Low Very Low Very Low
long-term potentiation 29 5.00 Very Low Very Low Very Low
positron emission tomography 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 48 99.92 Very High Very High Very High
Disease 489 99.84 Very High Very High Very High
Sprains And Strains 8 99.14 Very High Very High Very High
Aging 9 98.44 Very High Very High Very High
Vascular Dementia 9 98.20 Very High Very High Very High
Frontotemporal Dementia 21 97.56 Very High Very High Very High
Targeted Disruption 14 96.46 Very High Very High Very High
Ganglion Cysts 30 95.56 Very High Very High Very High
Retina Disease 1 93.04 High High
Stress 6 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding of endopeptidase-like cleavage of Tau, the insensitivity of the reaction to PSA inhibitors, together with the sensitivity of the reaction to the metal chelator o-phenanthroline suggest either contamination of the hPSASf preparation with a metallo-endopeptidase that cleaves Tau or that the cleavage of Tau by hPSASf proceeds through a novel mechanism.
Positive_regulation (cleavage) of Tau in cleavage
1) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.09
HEK293 cells expressing a tetracycline-inducible human 2N4R Tau were grown in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum, 5 ?
Positive_regulation (inducible) of Tau
2) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.09
When tested, with the exception of the original hPSASf (N-His6-hPSA with His tag removed), none of these other PSA preparations cleaved Tau 2N4R, figure 4.
Positive_regulation (cleaved) of Tau
3) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0
A stable tetracycline-inducible human Tau (2N4R) expressing cell line was obtained from Dr.
Positive_regulation (inducible) of Tau
4) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.06 Pain Relevance 0
The finding of endopeptidase-like cleavage of Tau, the insensitivity of the reaction to PSA inhibitors, together with the sensitivity of the reaction to the metal chelator o-phenanthroline suggest either contamination of the hPSASf preparation with a metallo-endopeptidase that cleaves Tau or that the cleavage of Tau by hPSASf proceeds through a novel mechanism.
Positive_regulation (cleaves) of Tau in cleavage
5) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.08
Studies in TauP301L transgenic mice in conjunction with a functional analysis in Drosophila associate Tau as being regulated by PSA [11] and a recent report showed that using an interference RNA against PSA increased Tau levels in SH-SY5Y cells [28].
Positive_regulation (increased) of Tau in SH-SY5Y associated with targeted disruption
6) Confidence 0.45 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.10 Pain Relevance 0
Moreover, the ability of increased p-tau assays to discriminate AD from normal aging and other dementia is more sensitive and specific than that of CSF concentrations of t-tau and A?
Positive_regulation (increased) of p-tau associated with dementia, aging and disease
7) Confidence 0.20 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.48 Pain Relevance 0
Furthermore, it has been shown that CSF GAP-43 and t-tau were increased in AD and correlated positively [123], suggesting both biomarkers are reflecting axonal and synaptic degeneration.

5.6.

Positive_regulation (increased) of t-tau associated with disease
8) Confidence 0.13 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.45 Pain Relevance 0
Although the CSF t-tau is very sensitive biomarker for detecting AD, it has limited ability to discriminate AD from other major forms of dementia as t-tau also increased in CSF of others form of dementia including vascular dementia (VAD) and frontotemporal dementia (FTD) [60].
Positive_regulation (increased) of t-tau associated with vascular dementia, dementia, frontotemporal dementia and disease
9) Confidence 0.13 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.28 Pain Relevance 0
Mice of either sex of a mixed B6/129 strain (10–16 weeks old) genetically modified to generate a tau-lacZ protein in place of the melanopsin protein (Hattar et al., 2002) were used in this study as well as 15–16 week old wild-type (C57BL/6J) and C3H/HeJ mice (homozygous for the retinal degeneration allele Pde6brd1).
Positive_regulation (generate) of tau-lacZ associated with sprains and strains and retina disease
10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.62 Pain Relevance 0.07
We generated a protein null allele by simultaneously introducing a tau-lacZ (tlz) reporter gene [29] in-frame into the initiation codon of the Neto1 gene (Figure 6A–6C).
Positive_regulation (introducing) of tau-lacZ
11) Confidence 0.02 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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