INT263691

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.24
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Neto1)
Anatomy Link Frequency
tail 1
hippocampus 1
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 48 93.24 High High
long-term potentiation 104 91.76 High High
Eae 8 80.56 Quite High
antagonist 4 33.36 Quite Low
addiction 4 26.64 Quite Low
Glutamate receptor 8 16.72 Low Low
nMDA receptor 36 5.00 Very Low Very Low Very Low
Pyramidal cell 16 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 32 91.08 High High
Congenital Anomalies 24 71.52 Quite High
Sprains And Strains 4 29.92 Quite Low
Convulsion 8 14.36 Low Low
Helminth Infection 4 5.00 Very Low Very Low Very Low
Influenza Virus Infection 4 5.00 Very Low Very Low Very Low
Contagious Ecthyma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our findings from the behavioural studies indicate that Neto1-null mice have broad deficiencies in spatial learning whereas the nonspatial task examined did not require Neto1.


Neg (not) Positive_regulation (require) of Neto1
1) Confidence 0.70 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.24 Pain Relevance 0.09
Taken together, these findings demonstrate that Neto1 is required for the normal abundance of synaptic NR2A-containing NMDARs and, as a result, for the normal contribution of NR2A-NMDARs to synaptic transmission and plasticity in CA1 hippocampus.


Positive_regulation (required) of Neto1 in hippocampus associated with hippocampus
2) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
The yeast two-hybrid system was initially used to determine whether the cytoplasmic tail of Neto1 could interact with PSD-95 and the related proteins PSD-93, SAP-102, and SAP-97.
Positive_regulation (tail) of Neto1 in tail
3) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
We next asked which NMDAR subunit mediates the Neto1:NMDAR interaction, using heterologously expressed proteins in HEK293 cells.
Positive_regulation (mediates) of Neto1
4) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

General Comments

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