INT263691

Context Info Confidence 0.70 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.24 Pain Relevance 0.17

plasma membrane (Neto1)

Anatomy Link Frequency tail 1 hippocampus 1 Neto1 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 48 93.24 long-term potentiation 104 91.76 Eae 8 80.56 antagonist 4 33.36 addiction 4 26.64 Glutamate receptor 8 16.72 nMDA receptor 36 5.00 Pyramidal cell 16 5.00 Central nervous system 12 5.00 Neurotransmitter 12 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 32 91.08 Congenital Anomalies 24 71.52 Sprains And Strains 4 29.92 Convulsion 8 14.36 Helminth Infection 4 5.00 Influenza Virus Infection 4 5.00 Contagious Ecthyma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together, our findings from the behavioural studies indicate that Neto1-null mice have broad deficiencies in spatial learning whereas the nonspatial task examined did not require Neto1.

Neg (not) Positive_regulation (require) of Neto1

1) Confidence 0.70 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.24 Pain Relevance 0.09

Taken together, these findings demonstrate that Neto1 is required for the normal abundance of synaptic NR2A-containing NMDARs and, as a result, for the normal contribution of NR2A-NMDARs to synaptic transmission and plasticity in CA1 hippocampus.

Positive_regulation (required) of Neto1 in hippocampus associated with hippocampus

2) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09

The yeast two-hybrid system was initially used to determine whether the cytoplasmic tail of Neto1 could interact with PSD-95 and the related proteins PSD-93, SAP-102, and SAP-97.

Positive_regulation (tail) of Neto1 in tail

3) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

We next asked which NMDAR subunit mediates the Neto1:NMDAR interaction, using heterologously expressed proteins in HEK293 cells.

Positive_regulation (mediates) of Neto1

4) Confidence 0.50 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.